The hypervariable gene locus PUM, which codes for the tumour associated epithelial mucins, is located on chromosome 1, within the region 1q21-24.

D. M. Swallow, S. Gendler, B. Griffiths, A. Kearney, S. Povey, D. Sheer, R. W. Palmer, J. Taylor-Papadimitriou

Research output: Contribution to journalArticle

Abstract

A single hypervariable autosomal gene locus, PUM, codes for a family of mucin-type glycoproteins present in human urine, and in several other normal and malignant tissues of epithelial origin. These mucins can be detected after electrophoresis using a series of monoclonal antibodies that show a pronounced tumour specificity on immunohistochemistry. Using a recently cloned cDNA, pMUC10, coding for the core protein of the PUM coded mucins, to probe DNA isolated from a series of human-rodent somatic cell hybrids, we have assigned the PUM locus to chromosome 1. This assignment was confirmed by in situ hybridization of pMUC10 to lymphocyte metaphase chromosomes and the gene was shown to be located within the region 1q21-24.

Original languageEnglish (US)
JournalAnnals of Human Genetics
Volume51
StatePublished - Oct 1987
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 1
Mucins
Genes
Neoplasms
Hybrid Cells
DNA Probes
Metaphase
In Situ Hybridization
Electrophoresis
Rodentia
Glycoproteins
Epithelium
Complementary DNA
Chromosomes
Immunohistochemistry
Monoclonal Antibodies
Urine
Lymphocytes
Proteins

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

The hypervariable gene locus PUM, which codes for the tumour associated epithelial mucins, is located on chromosome 1, within the region 1q21-24. / Swallow, D. M.; Gendler, S.; Griffiths, B.; Kearney, A.; Povey, S.; Sheer, D.; Palmer, R. W.; Taylor-Papadimitriou, J.

In: Annals of Human Genetics, Vol. 51, 10.1987.

Research output: Contribution to journalArticle

Swallow, D. M. ; Gendler, S. ; Griffiths, B. ; Kearney, A. ; Povey, S. ; Sheer, D. ; Palmer, R. W. ; Taylor-Papadimitriou, J. / The hypervariable gene locus PUM, which codes for the tumour associated epithelial mucins, is located on chromosome 1, within the region 1q21-24. In: Annals of Human Genetics. 1987 ; Vol. 51.
@article{a12e46221f8246e9bf993755a8f508e5,
title = "The hypervariable gene locus PUM, which codes for the tumour associated epithelial mucins, is located on chromosome 1, within the region 1q21-24.",
abstract = "A single hypervariable autosomal gene locus, PUM, codes for a family of mucin-type glycoproteins present in human urine, and in several other normal and malignant tissues of epithelial origin. These mucins can be detected after electrophoresis using a series of monoclonal antibodies that show a pronounced tumour specificity on immunohistochemistry. Using a recently cloned cDNA, pMUC10, coding for the core protein of the PUM coded mucins, to probe DNA isolated from a series of human-rodent somatic cell hybrids, we have assigned the PUM locus to chromosome 1. This assignment was confirmed by in situ hybridization of pMUC10 to lymphocyte metaphase chromosomes and the gene was shown to be located within the region 1q21-24.",
author = "Swallow, {D. M.} and S. Gendler and B. Griffiths and A. Kearney and S. Povey and D. Sheer and Palmer, {R. W.} and J. Taylor-Papadimitriou",
year = "1987",
month = "10",
language = "English (US)",
volume = "51",
journal = "Annals of Human Genetics",
issn = "0003-4800",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - The hypervariable gene locus PUM, which codes for the tumour associated epithelial mucins, is located on chromosome 1, within the region 1q21-24.

AU - Swallow, D. M.

AU - Gendler, S.

AU - Griffiths, B.

AU - Kearney, A.

AU - Povey, S.

AU - Sheer, D.

AU - Palmer, R. W.

AU - Taylor-Papadimitriou, J.

PY - 1987/10

Y1 - 1987/10

N2 - A single hypervariable autosomal gene locus, PUM, codes for a family of mucin-type glycoproteins present in human urine, and in several other normal and malignant tissues of epithelial origin. These mucins can be detected after electrophoresis using a series of monoclonal antibodies that show a pronounced tumour specificity on immunohistochemistry. Using a recently cloned cDNA, pMUC10, coding for the core protein of the PUM coded mucins, to probe DNA isolated from a series of human-rodent somatic cell hybrids, we have assigned the PUM locus to chromosome 1. This assignment was confirmed by in situ hybridization of pMUC10 to lymphocyte metaphase chromosomes and the gene was shown to be located within the region 1q21-24.

AB - A single hypervariable autosomal gene locus, PUM, codes for a family of mucin-type glycoproteins present in human urine, and in several other normal and malignant tissues of epithelial origin. These mucins can be detected after electrophoresis using a series of monoclonal antibodies that show a pronounced tumour specificity on immunohistochemistry. Using a recently cloned cDNA, pMUC10, coding for the core protein of the PUM coded mucins, to probe DNA isolated from a series of human-rodent somatic cell hybrids, we have assigned the PUM locus to chromosome 1. This assignment was confirmed by in situ hybridization of pMUC10 to lymphocyte metaphase chromosomes and the gene was shown to be located within the region 1q21-24.

UR - http://www.scopus.com/inward/record.url?scp=0023427010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023427010&partnerID=8YFLogxK

M3 - Article

C2 - 3447512

VL - 51

JO - Annals of Human Genetics

JF - Annals of Human Genetics

SN - 0003-4800

ER -