The human serotonin 5-HT2B receptor: Pharmacological link between 5-HT2 and 5-HT1D receptors

Doo Sup Choi, Guillaume Birraux, Jean Marie Launay, Luc Maroteaux

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

The human serotonin 5-HT2B receptor, isolated from a human liver cDNA library, was transfected in COS-1 cells. Its pharmacological profile shows divergence with serotonin 5-HT2B receptors of other species. In particular, although strong correlation is observed between the human and the rat 5-HT2B receptor pharmacology, the correlation is almost as significant for the mouse 5-HT2B and the human 5-HT1D receptor agonists. The major sites of expression of its mRNA are in the human liver and kidney, with detectable expression in lung and heart. Therefore, this human 5-HT2B receptor could account for functions attributed to the peripheral 5-HT1D/5-HT2-like receptors, especially in the cardiovascular system. Thus, its detailed original pharmacology is of prime importance for therapeutic drug development.

Original languageEnglish (US)
Pages (from-to)393-399
Number of pages7
JournalFEBS Letters
Volume352
Issue number3
DOIs
StatePublished - Oct 3 1994

Keywords

  • Cardiovascular system
  • DOI binding
  • G protein-coupled receptor
  • Polymerase chain reaction
  • cDNA cloning

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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