The human serotonin 5-HT2B receptor: Pharmacological link between 5-HT2 and 5-HT1D receptors

Doo Sup Choi, Guillaume Birraux, Jean Marie Launay, Luc Maroteaux

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The human serotonin 5-HT2B receptor, isolated from a human liver cDNA library, was transfected in COS-1 cells. Its pharmacological profile shows divergence with serotonin 5-HT2B receptors of other species. In particular, although strong correlation is observed between the human and the rat 5-HT2B receptor pharmacology, the correlation is almost as significant for the mouse 5-HT2B and the human 5-HT1D receptor agonists. The major sites of expression of its mRNA are in the human liver and kidney, with detectable expression in lung and heart. Therefore, this human 5-HT2B receptor could account for functions attributed to the peripheral 5-HT1D/5-HT2-like receptors, especially in the cardiovascular system. Thus, its detailed original pharmacology is of prime importance for therapeutic drug development.

Original languageEnglish (US)
Pages (from-to)393-399
Number of pages7
JournalFEBS Letters
Volume352
Issue number3
DOIs
StatePublished - Oct 3 1994
Externally publishedYes

Fingerprint

Receptor, Serotonin, 5-HT2B
Receptor, Serotonin, 5-HT1D
Pharmacology
Liver
Cardiovascular system
Gene Library
Serotonin 5-HT1 Receptor Agonists
Rats
COS Cells
Cardiovascular System
Messenger RNA
Pharmaceutical Preparations
Kidney
Lung

Keywords

  • Cardiovascular system
  • cDNA cloning
  • DOI binding
  • G protein-coupled receptor
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

The human serotonin 5-HT2B receptor : Pharmacological link between 5-HT2 and 5-HT1D receptors. / Choi, Doo Sup; Birraux, Guillaume; Launay, Jean Marie; Maroteaux, Luc.

In: FEBS Letters, Vol. 352, No. 3, 03.10.1994, p. 393-399.

Research output: Contribution to journalArticle

Choi, Doo Sup ; Birraux, Guillaume ; Launay, Jean Marie ; Maroteaux, Luc. / The human serotonin 5-HT2B receptor : Pharmacological link between 5-HT2 and 5-HT1D receptors. In: FEBS Letters. 1994 ; Vol. 352, No. 3. pp. 393-399.
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