TY - JOUR
T1 - The Human Brain Subventricular Zone
T2 - Stem Cells in This Niche and Its Organization
AU - Quiñones-Hinojosa, Alfredo
AU - Sanai, Nader
AU - Gonzalez-Perez, Oscar
AU - Garcia-Verdugo, Jose Manuel
PY - 2007/1
Y1 - 2007/1
N2 - Taken together, these observations offer direct evidence that this germinal region is not only organized differently but contains cells with astrocytic characteristics that function as neural stem cells. Considering the size of the human lateral ventricular system, this work suggests that a substantial number of neural stem cells exist in the adult brain throughout life. Understanding the organization of the adult human SVZ represents a necessary first step in understanding the cellular proliferation, precursor migration, and neurogenic niche of the largest known germinal region in the adult human brain-a foundation on which to develop novel neuroregenerative therapies.
AB - Taken together, these observations offer direct evidence that this germinal region is not only organized differently but contains cells with astrocytic characteristics that function as neural stem cells. Considering the size of the human lateral ventricular system, this work suggests that a substantial number of neural stem cells exist in the adult brain throughout life. Understanding the organization of the adult human SVZ represents a necessary first step in understanding the cellular proliferation, precursor migration, and neurogenic niche of the largest known germinal region in the adult human brain-a foundation on which to develop novel neuroregenerative therapies.
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U2 - 10.1016/j.nec.2006.10.013
DO - 10.1016/j.nec.2006.10.013
M3 - Review article
C2 - 17244550
AN - SCOPUS:33846522223
SN - 1042-3680
VL - 18
SP - 15
EP - 20
JO - Neurosurgery clinics of North America
JF - Neurosurgery clinics of North America
IS - 1
ER -