The Human Brain Subventricular Zone: Stem Cells in This Niche and Its Organization

Alfredo Quinones-Hinojosa, Nader Sanai, Oscar Gonzalez-Perez, Jose Manuel Garcia-Verdugo

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Taken together, these observations offer direct evidence that this germinal region is not only organized differently but contains cells with astrocytic characteristics that function as neural stem cells. Considering the size of the human lateral ventricular system, this work suggests that a substantial number of neural stem cells exist in the adult brain throughout life. Understanding the organization of the adult human SVZ represents a necessary first step in understanding the cellular proliferation, precursor migration, and neurogenic niche of the largest known germinal region in the adult human brain-a foundation on which to develop novel neuroregenerative therapies.

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalNeurosurgery Clinics of North America
Volume18
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

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Lateral Ventricles
Stem Cells
Neural Stem Cells
Brain
Cell Proliferation
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

The Human Brain Subventricular Zone : Stem Cells in This Niche and Its Organization. / Quinones-Hinojosa, Alfredo; Sanai, Nader; Gonzalez-Perez, Oscar; Garcia-Verdugo, Jose Manuel.

In: Neurosurgery Clinics of North America, Vol. 18, No. 1, 01.2007, p. 15-20.

Research output: Contribution to journalReview article

Quinones-Hinojosa, Alfredo ; Sanai, Nader ; Gonzalez-Perez, Oscar ; Garcia-Verdugo, Jose Manuel. / The Human Brain Subventricular Zone : Stem Cells in This Niche and Its Organization. In: Neurosurgery Clinics of North America. 2007 ; Vol. 18, No. 1. pp. 15-20.
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