The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif

Ricardo Medina, Timothy Buck, Sayyed K. Zaidi, Angela Miele-Chamberland, Jane B. Lian, Janet L. Stein, Andre J. Van Wijnen, Gary S. Stein

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Accumulation of histone proteins is necessary for packaging of replicated DNA during the S phase of the cell cycle. Different mechanisms operate to regulate histone protein levels, and induction of human histone gene expression at the G1-S phase transition plays a critical role. The zinc finger HiNF-P and coactivator p220NPAT proteins are key regulators of histone gene expression. Here, we describe a novel HiNF-P-specific conserved region (PSCR) located within the C-terminus that is present in HiNF-P homologues of all metazoan species that have been examined. The PSCR motif is required for activation of histone H4 gene transcription and contributes to DNA binding of HiNF-P. Thus, the PSCR module represents an auxiliary DNA-binding determinant that plays a critical role in mediating histone gene expression during the cell cycle and defines HiNF-P as a unique cell cycle regulatory member of the zinc finger transcription factor family.

Original languageEnglish (US)
Pages (from-to)11415-11423
Number of pages9
JournalBiochemistry
Volume47
Issue number44
DOIs
StatePublished - Nov 4 2008

ASJC Scopus subject areas

  • Biochemistry

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    Medina, R., Buck, T., Zaidi, S. K., Miele-Chamberland, A., Lian, J. B., Stein, J. L., Van Wijnen, A. J., & Stein, G. S. (2008). The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif. Biochemistry, 47(44), 11415-11423. https://doi.org/10.1021/bi800961d