The HemeScan test for genomic prognostic marker assessment in chronic lymphocytic leukemia

Shelly R. Gunn, Mansoor S. Mohammed, Clemens H.M. Mellink, Lynne V. Abruzzo, Ryan S. Robetorye

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Whole-genome analysis by array-based comparative genomic hybridization (array CGH) is an emerging technique for the detection of recurrent unbalanced chromosomal aberrations in chronic lymphocytic leukemia (CLL). These chromosomal changes can be highly predictive of clinical course and are evaluated at present using classical cytogenetics and interphase fluorescence in situ hybridization. However, the significant limitations of these assays have resulted in efforts to move array CGH from use as a discovery tool in the research laboratory into the clinical laboratory as an alternative method for the evaluation of genomic prognostic markers in patients with CLL. Objective: The HemeScan™ array was developed as a clinical tool to provide prognostic marker identification with simultaneous diagnostic monitoring of the entire genome in CLL and other hematological malignancies. Methods: The authors review representative data from clinical testing of HemeScan for genomic aberration identification in CLL and present suggestions for the integration of array CGH genome scanning into the clinical laboratory. Results/conclusion: The HemeScan assay for CLL precludes the need for G-banded cytognetics by simultaneously revealing prognostic marker status and the level of genomic complexity in > 85% of cases.

Original languageEnglish (US)
Pages (from-to)731-740
Number of pages10
JournalExpert Opinion on Medical Diagnostics
Volume2
Issue number6
DOIs
StatePublished - Jun 1 2008

Keywords

  • Array CGH
  • Chronic lymphocytic leukemia
  • HemeScan™
  • Prognostic markers

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Medicine
  • Biochemistry, medical

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