The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans

D. Herminghuysen, C. Cook, H. Thompson, D. Bostick, F. Lee, L. Stokes, C. Hilton, C. Prasad

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Histidyl-proline diketopiperazine (CHP) is a cyclic dipeptide that is found in many animal tissues, most notably brain and gut. It has been found to have a variety of biologic actions and has been postulated to play a role in appetitive behavior and energy metabolism. This study was conducted in order to characterize the secretory pattern of CHP during a 24 h fast. Four subjects (2 obese and 2 lean) were studied during the latter 24 h of a 36 h fast. Blood was sampled every 10-15 min and assayed for CHP concentration using a specific radioimmunoassay. Analysis revealed that circulating CHP oscillates in humans and that diurnal variation occurred but only in the obese subjects.

Original languageEnglish (US)
Pages (from-to)273-280
Number of pages8
JournalNeuropeptides
Volume26
Issue number4
DOIs
StatePublished - Apr 1994

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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    Herminghuysen, D., Cook, C., Thompson, H., Bostick, D., Lee, F., Stokes, L., Hilton, C., & Prasad, C. (1994). The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans. Neuropeptides, 26(4), 273-280. https://doi.org/10.1016/0143-4179(94)90082-5