The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans

D. Herminghuysen, C. Cook, H. Thompson, D. Bostick, F. Lee, L. Stokes, C. Hilton, C. Prasad

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Histidyl-proline diketopiperazine (CHP) is a cyclic dipeptide that is found in many animal tissues, most notably brain and gut. It has been found to have a variety of biologic actions and has been postulated to play a role in appetitive behavior and energy metabolism. This study was conducted in order to characterize the secretory pattern of CHP during a 24 h fast. Four subjects (2 obese and 2 lean) were studied during the latter 24 h of a 36 h fast. Blood was sampled every 10-15 min and assayed for CHP concentration using a specific radioimmunoassay. Analysis revealed that circulating CHP oscillates in humans and that diurnal variation occurred but only in the obese subjects.

Original languageEnglish (US)
Pages (from-to)273-280
Number of pages8
JournalNeuropeptides
Volume26
Issue number4
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Appetitive Behavior
Dipeptides
Energy Metabolism
Radioimmunoassay
Fasting
Brain
Animals
Blood
Tissue
Peptides
histidyl-proline diketopiperazine

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Herminghuysen, D., Cook, C., Thompson, H., Bostick, D., Lee, F., Stokes, L., ... Prasad, C. (1994). The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans. Neuropeptides, 26(4), 273-280. https://doi.org/10.1016/0143-4179(94)90082-5

The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans. / Herminghuysen, D.; Cook, C.; Thompson, H.; Bostick, D.; Lee, F.; Stokes, L.; Hilton, C.; Prasad, C.

In: Neuropeptides, Vol. 26, No. 4, 1994, p. 273-280.

Research output: Contribution to journalArticle

Herminghuysen, D, Cook, C, Thompson, H, Bostick, D, Lee, F, Stokes, L, Hilton, C & Prasad, C 1994, 'The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans', Neuropeptides, vol. 26, no. 4, pp. 273-280. https://doi.org/10.1016/0143-4179(94)90082-5
Herminghuysen, D. ; Cook, C. ; Thompson, H. ; Bostick, D. ; Lee, F. ; Stokes, L. ; Hilton, C. ; Prasad, C. / The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans. In: Neuropeptides. 1994 ; Vol. 26, No. 4. pp. 273-280.
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