The growing incidence and severity of Clostridium difficile infection in inpatient and outpatient settings

Sahil Khanna, Darrell S. Pardi

Research output: Contribution to journalReview articlepeer-review

137 Scopus citations

Abstract

Clostridium difficile infection (CDI) is a leading cause of nosocomial infections, with disease severity ranging from mild diarrhea to fulminant colitis. The incidence and severity of CDI has been on the rise over the last 10-20 years, with CDI being increasingly described outside healthcare settings and in populations previously thought to be at low risk. There has also been an increase in the morbidity, mortality and economic burden associated with CDI in the last several years. This increasing incidence and severity is thought to be at least partially due to frequent antibiotic use and the emergence of a hypervirulent C. difficile strain.

Original languageEnglish (US)
Pages (from-to)409-416
Number of pages8
JournalExpert Review of Gastroenterology and Hepatology
Volume4
Issue number4
DOIs
StatePublished - Aug 1 2010

Keywords

  • Clostridium difficile infection
  • colitis
  • community acquired
  • nosocomial

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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