The Glioma International Case-Control Study: A Report from the Genetic Epidemiology of Glioma International Consortium

E. Susan Amirian, Georgina N. Armstrong, Renke Zhou, Ching C. Lau, Elizabeth B. Claus, Jill S. Barnholtz-Sloan, Dora Il'Yasova, Joellen Schildkraut, Francis Ali-Osman, Siegal Sadetzki, Christoffer Johansen, Richard S. Houlston, Robert Brian Jenkins, Daniel H Lachance, Sara H. Olson, Jonine L. Bernstein, Ryan T. Merrell, Margaret R. Wrensch, Faith G. Davis, Rose LaiSanjay Shete, Christopher I. Amos, Michael E. Scheurer, Kenneth Aldape, Irina Alafuzoff, Thomas Brännström, Helle Broholm, Peter Collins, Caterina Giannini, Marc Rosenblum, Tarik Tihan, Beatrice S. Melin, Melissa L. Bondy

Research output: Contribution to journalArticle

29 Scopus citations


Decades of research have established only a few etiological factors for glioma, which is a rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity of tumor subtypes, and retrospective exposure assessment. Here, we briefly describe the Glioma International Case-Control (GICC) Study (recruitment, 2010-2013), a study being conducted by the Genetic Epidemiology of Glioma International Consortium that integrates data from multiple data collection sites, uses a common protocol and questionnaire, and includes biospecimen collection. To our knowledge, the GICC Study is the largest glioma study to date that includes collection of blood samples, which will allow for genetic analysis and interrogation of gene-environment interactions.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalAmerican Journal of Epidemiology
Issue number2
StatePublished - Jan 15 2016



  • cancer
  • case-control studies
  • glioblastoma
  • glioma
  • methodology
  • study profile

ASJC Scopus subject areas

  • Epidemiology

Cite this

Amirian, E. S., Armstrong, G. N., Zhou, R., Lau, C. C., Claus, E. B., Barnholtz-Sloan, J. S., Il'Yasova, D., Schildkraut, J., Ali-Osman, F., Sadetzki, S., Johansen, C., Houlston, R. S., Jenkins, R. B., Lachance, D. H., Olson, S. H., Bernstein, J. L., Merrell, R. T., Wrensch, M. R., Davis, F. G., ... Bondy, M. L. (2016). The Glioma International Case-Control Study: A Report from the Genetic Epidemiology of Glioma International Consortium. American Journal of Epidemiology, 183(2), 85-91.