The genetic basis for variation in antibody response to vaccines

Gregory A. Poland, Robert M. Jacobson

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Following a brief review of important concepts of vaccine response and vaccine immunology, recent reports on genetic determinants of vaccine response are reviewed. Recent data demonstrating significant associations with particular human leukocyte antigen genes and responsiveness to measles and hepatitis B vaccines are discussed, along with the influence of Km and Gm allotype genes on pneumococcal polysaccharide vaccines. These recent findings have important considerations for research, vaccine development, and clinical practice.

Original languageEnglish (US)
Pages (from-to)208-215
Number of pages8
JournalCurrent Opinion in Pediatrics
Volume10
Issue number2
DOIs
StatePublished - 1998

Fingerprint

Antibody Formation
Vaccines
Immunoglobulin Km Allotypes
Immunoglobulin Gm Allotypes
Hepatitis B Vaccines
Pneumococcal Vaccines
Measles
HLA Antigens
Allergy and Immunology
Genes
Research

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The genetic basis for variation in antibody response to vaccines. / Poland, Gregory A.; Jacobson, Robert M.

In: Current Opinion in Pediatrics, Vol. 10, No. 2, 1998, p. 208-215.

Research output: Contribution to journalArticle

Poland, Gregory A. ; Jacobson, Robert M. / The genetic basis for variation in antibody response to vaccines. In: Current Opinion in Pediatrics. 1998 ; Vol. 10, No. 2. pp. 208-215.
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