The genetic basis for interindividual immune response variation to measles vaccine: New understanding and new vaccine approaches

Iana H. Haralambieva, Inna G. Ovsyannikova, V. Shane Pankratz, Richard B. Kennedy, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

The live-attenuated measles vaccine is effective, but measles outbreaks still occur in vaccinated populations. This warrants elucidation of the determinants of measles vaccine-induced protective immunity. Interindividual variability in markers of measles vaccine-induced immunity, including neutralizing antibody levels, is regulated in part by host genetic factor variations. This review summarizes recent advances in our understanding of measles vaccine immunogenetics relative to the perspective of developing better measles vaccines. Important genetic regulators of measles vaccine-induced immunity, such as HLA class I and HLA class II genotypes, single nucleotide polymorphisms in cytokine/cytokine receptor genes (IL12B, IL12RB1, IL2, IL10) and the cell surface measles virus receptor CD46 gene, have been identified and independently replicated. New technologies present many opportunities for identification of novel genetic signatures and genetic architectures. These findings help explain a variety of immune response-related phenotypes and promote a new paradigm of 'vaccinomics' for novel vaccine development.

Original languageEnglish (US)
Pages (from-to)57-70
Number of pages14
JournalExpert review of vaccines
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • adaptive immunity
  • genetic association studies
  • human leukocyte antigens
  • immunogenetics
  • measles vaccine
  • single nucleotide polymorphisms

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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