The genetic basis for interindividual immune response variation to measles vaccine: New understanding and new vaccine approaches

Iana H. Haralambieva, Inna G. Ovsyannikova, V. Shane Pankratz, Richard B Kennedy, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The live-attenuated measles vaccine is effective, but measles outbreaks still occur in vaccinated populations. This warrants elucidation of the determinants of measles vaccine-induced protective immunity. Interindividual variability in markers of measles vaccine-induced immunity, including neutralizing antibody levels, is regulated in part by host genetic factor variations. This review summarizes recent advances in our understanding of measles vaccine immunogenetics relative to the perspective of developing better measles vaccines. Important genetic regulators of measles vaccine-induced immunity, such as HLA class I and HLA class II genotypes, single nucleotide polymorphisms in cytokine/cytokine receptor genes (IL12B, IL12RB1, IL2, IL10) and the cell surface measles virus receptor CD46 gene, have been identified and independently replicated. New technologies present many opportunities for identification of novel genetic signatures and genetic architectures. These findings help explain a variety of immune response-related phenotypes and promote a new paradigm of 'vaccinomics' for novel vaccine development.

Original languageEnglish (US)
Pages (from-to)57-70
Number of pages14
JournalExpert Review of Vaccines
Volume12
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Measles Vaccine
Vaccines
Immunity
Marker Vaccines
Virus Receptors
Immunogenetics
Attenuated Vaccines
Measles virus
Cytokine Receptors
Measles
Neutralizing Antibodies
Interleukin-10
Genes
Interleukin-2
Single Nucleotide Polymorphism
Disease Outbreaks
Genotype
Cytokines
Technology
Phenotype

Keywords

  • adaptive immunity
  • genetic association studies
  • human leukocyte antigens
  • immunogenetics
  • measles vaccine
  • single nucleotide polymorphisms

ASJC Scopus subject areas

  • Immunology
  • Drug Discovery
  • Pharmacology
  • Molecular Medicine

Cite this

The genetic basis for interindividual immune response variation to measles vaccine : New understanding and new vaccine approaches. / Haralambieva, Iana H.; Ovsyannikova, Inna G.; Pankratz, V. Shane; Kennedy, Richard B; Jacobson, Robert M.; Poland, Gregory A.

In: Expert Review of Vaccines, Vol. 12, No. 1, 01.2013, p. 57-70.

Research output: Contribution to journalArticle

Haralambieva, Iana H. ; Ovsyannikova, Inna G. ; Pankratz, V. Shane ; Kennedy, Richard B ; Jacobson, Robert M. ; Poland, Gregory A. / The genetic basis for interindividual immune response variation to measles vaccine : New understanding and new vaccine approaches. In: Expert Review of Vaccines. 2013 ; Vol. 12, No. 1. pp. 57-70.
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