The generation and function of soluble apoE receptors in the CNS

G. William Rebeck, Mary Jo LaDu, Steven Estus, Guojun Bu, Edwin J. Weeber

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

More than a decade has passed since apolipoprotein E4 (APOE-ε4) was identified as a primary risk factor for Alzheimer's disease (AD), yet researchers are even now struggling to understand how the apolipoprotein system integrates into the puzzle of AD etiology. The specific pathological actions of apoE4, methods of modulating apolipoprotein E4-associated risk, and possible roles of apoE in normal synaptic function are still being debated. These critical questions will never be fully answered without a complete understanding of the life cycle of the apolipoprotein receptors that mediate the uptake, signaling, and degradation of apoE. The present review will focus on apoE receptors as modulators of apoE actions and, in particular, explore the functions of soluble apoE receptors, a field almost entirely overlooked until now.

Original languageEnglish (US)
Article number15
JournalMolecular neurodegeneration
Volume1
Issue number1
DOIs
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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