The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13

Richard J Bram, Virginia Valentine, David N. Shapiro, Nancy A. Jenkins, Debra J. Gilbert, Neal G. Copeland

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The CAMLG gene encodes a novel cyclophilin B-binding protein called calcium-modulating cyclophilin ligand, which appears to be involved in the regulation of calcium signaling in T lymphocytes and other cells. The murine homolog, Caml, was localized by interspecific backcross analysis to the middle of chromosome 13. By fluorescence in situ hybridization, this gene was localized to human chromosome 5 in a region (q23) known to be syntenic to mouse chromosome 13. These results provide further evidence supporting the extensive homology between human chromosome 5q and mouse chromosome 13. In addition, the results will provide a basis for further evaluation of cytogenetic anomalies that may contribute to inherited defects in calcium signaling or immune system function.

Original languageEnglish (US)
Pages (from-to)257-260
Number of pages4
JournalGenomics
Volume31
Issue number2
DOIs
StatePublished - Jan 15 1996
Externally publishedYes

Fingerprint

Cyclophilins
Chromosomes, Human, Pair 13
Human Chromosomes
Calcium Signaling
Ligands
Calcium
Genes
Chromosomes, Human, Pair 5
Calcium-Binding Proteins
Fluorescence In Situ Hybridization
Cytogenetics
Immune System
T-Lymphocytes

ASJC Scopus subject areas

  • Genetics

Cite this

The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13. / Bram, Richard J; Valentine, Virginia; Shapiro, David N.; Jenkins, Nancy A.; Gilbert, Debra J.; Copeland, Neal G.

In: Genomics, Vol. 31, No. 2, 15.01.1996, p. 257-260.

Research output: Contribution to journalArticle

Bram, Richard J ; Valentine, Virginia ; Shapiro, David N. ; Jenkins, Nancy A. ; Gilbert, Debra J. ; Copeland, Neal G. / The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13. In: Genomics. 1996 ; Vol. 31, No. 2. pp. 257-260.
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