The G0/G1 switch gene 2 (G0S2): Regulating metabolism and beyond

Bradlee L. Heckmann, Xiaodong Zhang, Xitao Xie, Jun Liu

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations


The G0/G1 switch gene 2 (G0S2) was originally identified in blood mononuclear cells following induced cell cycle progression. Translation of G0S2 results in a small basic protein of 103 amino acids in size. It was initially believed that G0S2 mediates re-entry of cells from the G0 to G1 phase of the cell cycle. Recent studies have begun to reveal the functional aspects of G0S2 and its protein product in various cellular settings. To date the best-known function of G0S2 is its direct inhibitory capacity on the rate-limiting lipolytic enzyme adipose triglyceride lipase (ATGL). Other studies have illustrated key features of G0S2 including sub-cellular localization, expression profiles and regulation, and possible functions in cellular proliferation and differentiation. In this review we present the current knowledge base regarding all facets of G0S2, and pose a variety of questions and hypotheses pertaining to future research directions.

Original languageEnglish (US)
Pages (from-to)276-281
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Issue number2
StatePublished - Feb 2013


  • Apoptosis
  • Cell cycle
  • Cell proliferation
  • Differentiation
  • G0/G1 switch gene 2
  • G0S2
  • Lipolysis

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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