The future of perioperative therapy in advanced renal cell carcinoma: How can we PROSPER?

Hiten D. Patel, Maneka Puligandla, Brian M. Shuch, Bradley Leibovich, Anil Kapoor, Viraj A. Master, Charles G. Drake, Daniel Y.C. Heng, Primo N. Lara, Toni K. Choueiri, Deborah Maskens, Eric A. Singer, Scott E. Eggener, Robert S. Svatek, Walter M. Stadler, Suzanne Cole, Sabina Signoretti, Rajan T. Gupta, Marc Dror Michaelson, David F. McDermottDavid Cella, Lynne I. Wagner, Naomi B. Haas, Michael A. Carducci, Lauren C. Harshman, Mohamad E. Allaf

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

While many patients with early stage kidney cancer can be cured by removal of the tumor and kidney ('nephrectomy'), upward of 40% of patients can recur due to microscopic spread of the cancer prior to surgery. Adding anticancer drugs that are effective in the metastatic setting to surgery has potential to eliminate the microscopic disease and increase cure rates. The PROSPER renal cell carcinoma study is testing whether adding nivolumab, a drug that engages the immune system to better recognize, fight and eliminate the cancer, will improve disease control over surgery alone. Nivolumab will be given before and after surgery to see if it reduces the chance of the disease returning and decreases death from kidney cancer compared with patients receiving surgery only.

Original languageEnglish (US)
Pages (from-to)1683-1695
Number of pages13
JournalFuture Oncology
Volume15
Issue number15
DOIs
StatePublished - May 1 2019

    Fingerprint

Keywords

  • clinical trial
  • kidney cancer
  • neoadjuvant therapy
  • nephrectomy
  • nivolumab
  • perioperative
  • presurgical
  • PROSPER RCC
  • renal cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Patel, H. D., Puligandla, M., Shuch, B. M., Leibovich, B., Kapoor, A., Master, V. A., Drake, C. G., Heng, D. Y. C., Lara, P. N., Choueiri, T. K., Maskens, D., Singer, E. A., Eggener, S. E., Svatek, R. S., Stadler, W. M., Cole, S., Signoretti, S., Gupta, R. T., Michaelson, M. D., ... Allaf, M. E. (2019). The future of perioperative therapy in advanced renal cell carcinoma: How can we PROSPER? Future Oncology, 15(15), 1683-1695. https://doi.org/10.2217/fon-2018-0951