The Forgotten Role of Glucose Effectiveness in the Regulation of Glucose Tolerance

Simmi Dube, Isabel Errazuriz-Cruzat, Ananda Basu, Rita Basu

Research output: Contribution to journalArticle

16 Scopus citations


Glucose effectiveness (S<inf>G</inf>) is the ability of glucose per se to stimulate its own uptake and to suppress its own production under basal/constant insulin concentrations. In an individual, glucose tolerance is a function of insulin secretion, insulin action and S<inf>G</inf>. Under conditions of declining insulin secretion and action (e.g. type 2 diabetes), the degree of S<inf>G</inf> assumes increasing significance in determining the level of glucose tolerance both in fasted and postprandial states. Although the importance of S<inf>G</inf> has been recognized for years, mechanisms that contribute to S<inf>G</inf> are poorly understood. Research data on modulation of S<inf>G</inf> and its impact in glucose intolerance is limited. In this review, we will focus on the role of S<inf>G</inf> in the regulation of glucose tolerance, its evaluation, and potential advantages of therapies that can enhance glucose-induced stimulation of glucose uptake and suppression of its own production in conditions of impaired insulin secretion and action.

Original languageEnglish (US)
JournalCurrent Diabetes Reports
Issue number6
StatePublished - Jun 1 2015


  • Diabetes
  • Glucose effectiveness
  • Glucose tolerance

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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