The feasibility of integrating elastography measurements into mri-guided transurethral ultrasound therapy

Arvin Forghanian-Arani, Yuexi Huang, Michael Bronskill, Rajiv Chopra

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

MRI-guided transurethral ultrasound therapy is being developed as a minimally invasive treatment for localized prostate cancer. The capability to identify target regions prior to therapy would provide an integrated diagnostic and therapeutic solution to the management of this disease. The objective of this project is to evaluate the feasibility of performing elastography using a transurethral actuator. Shear waves were generated in the prostate by vibrating the transurethral actuator longitudinally and resolving the tissue displacements with a 1.5 Tesla MRI. A piezoelectric actuator was used to vibrate the transurethral device with an amplitude of 32um at frequencies of 100 and 250Hz. GRE imaging sequences with displacement encoded along the direction of vibration were acquired transverse and parallel to the rod to visualize the dynamics of wave propagation. Experiments were performed in phantoms (8% gelatin) and in a canine model (n=5). Vibration was achieved in the MRI without significant loss of SNR in the images. The shear waves produced in the gel were cylindrical in nature, and extended along the length of the rod. Shear wave propagation in the canine prostate gland was observed at 100 and 250Hz, and shear modulus values agreed with previously published values.

Original languageEnglish (US)
Title of host publication8th International Symposium on Therapeutic Ultrasound
Pages265-269
Number of pages5
DOIs
StatePublished - Jul 21 2009
Externally publishedYes
Event8th International Symposium on Therapeutic Ultrasound - Minneapolis, MN, United States
Duration: Sep 10 2008Sep 13 2008

Publication series

NameAIP Conference Proceedings
Volume1113
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference8th International Symposium on Therapeutic Ultrasound
CountryUnited States
CityMinneapolis, MN
Period9/10/089/13/08

Fingerprint

shear stress
S waves
S-wave
therapy
therapeutics
wave propagation
vibration
rods
actuators
prostate gland
piezoelectric actuators
gelatins
shear modulus
dogs
cancer
prostatic neoplasms
gel
gelatin
gels
shear

Keywords

  • Feasibility
  • MR elastography
  • MRI
  • Prostate Cancer
  • Prostate imaging
  • Transurethral

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Plant Science
  • Physics and Astronomy(all)
  • Nature and Landscape Conservation

Cite this

Forghanian-Arani, A., Huang, Y., Bronskill, M., & Chopra, R. (2009). The feasibility of integrating elastography measurements into mri-guided transurethral ultrasound therapy. In 8th International Symposium on Therapeutic Ultrasound (pp. 265-269). (AIP Conference Proceedings; Vol. 1113). https://doi.org/10.1063/1.3131428

The feasibility of integrating elastography measurements into mri-guided transurethral ultrasound therapy. / Forghanian-Arani, Arvin; Huang, Yuexi; Bronskill, Michael; Chopra, Rajiv.

8th International Symposium on Therapeutic Ultrasound. 2009. p. 265-269 (AIP Conference Proceedings; Vol. 1113).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Forghanian-Arani, A, Huang, Y, Bronskill, M & Chopra, R 2009, The feasibility of integrating elastography measurements into mri-guided transurethral ultrasound therapy. in 8th International Symposium on Therapeutic Ultrasound. AIP Conference Proceedings, vol. 1113, pp. 265-269, 8th International Symposium on Therapeutic Ultrasound, Minneapolis, MN, United States, 9/10/08. https://doi.org/10.1063/1.3131428
Forghanian-Arani A, Huang Y, Bronskill M, Chopra R. The feasibility of integrating elastography measurements into mri-guided transurethral ultrasound therapy. In 8th International Symposium on Therapeutic Ultrasound. 2009. p. 265-269. (AIP Conference Proceedings). https://doi.org/10.1063/1.3131428
Forghanian-Arani, Arvin ; Huang, Yuexi ; Bronskill, Michael ; Chopra, Rajiv. / The feasibility of integrating elastography measurements into mri-guided transurethral ultrasound therapy. 8th International Symposium on Therapeutic Ultrasound. 2009. pp. 265-269 (AIP Conference Proceedings).
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