The Fate of Acute Methicillin-Resistant Staphylococcus aureus Periprosthetic Knee Infections Treated by Open Debridement and Retention of Components

Thomas Bradbury, Thomas K. Fehring, Michael Taunton, Arlen Hanssen, Khalid Azzam, Javad Parvizi, Susan M. Odum

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

The success of open irrigation and debridement with component retention (ODCR) for acute periprosthetic knee joint infection varies widely. The species and virulence of the infecting organism have been shown to influence outcome. This multicenter, retrospective study identified 19 cases of acute periprosthetic methicillin-resistant Staphylococcus aureus (MRSA) knee infections managed by ODCR and at least 4 weeks of postoperative intravenous vancomycin therapy. At minimum follow-up of 2 years, the treatment failed to eradicate the infection in 16 cases (84% failure rate). Of those 16 failures, 13 patients required a 2-stage exchange arthroplasty, 2 patients required repeat incision and debridement with antibiotic suppression, and 1 patient died of MRSA sepsis. In addition, a systematic review of the literature revealed failure to eradicate infection in 10 of 13 patients managed with a similar protocol. The total success rate of ODCR in acute periprosthetic MRSA knee infection was 18%.

Original languageEnglish (US)
Pages (from-to)101-104
Number of pages4
JournalJournal of Arthroplasty
Volume24
Issue number6 SUPPL.
DOIs
StatePublished - Sep 2009

Fingerprint

Debridement
Methicillin-Resistant Staphylococcus aureus
Knee
Infection
Vancomycin
Knee Joint
Arthroplasty
Multicenter Studies
Virulence
Sepsis
Retrospective Studies
Anti-Bacterial Agents
Therapeutics

Keywords

  • MRSA
  • open debridement
  • retention of components
  • TKA

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

The Fate of Acute Methicillin-Resistant Staphylococcus aureus Periprosthetic Knee Infections Treated by Open Debridement and Retention of Components. / Bradbury, Thomas; Fehring, Thomas K.; Taunton, Michael; Hanssen, Arlen; Azzam, Khalid; Parvizi, Javad; Odum, Susan M.

In: Journal of Arthroplasty, Vol. 24, No. 6 SUPPL., 09.2009, p. 101-104.

Research output: Contribution to journalArticle

Bradbury, Thomas ; Fehring, Thomas K. ; Taunton, Michael ; Hanssen, Arlen ; Azzam, Khalid ; Parvizi, Javad ; Odum, Susan M. / The Fate of Acute Methicillin-Resistant Staphylococcus aureus Periprosthetic Knee Infections Treated by Open Debridement and Retention of Components. In: Journal of Arthroplasty. 2009 ; Vol. 24, No. 6 SUPPL. pp. 101-104.
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