The famine exposure in early life and metabolic syndrome in adulthood

Ningjian Wang, Xiaojin Wang, Qin Li, Bing Han, Yi Chen, Chunfang Zhu, Yingchao Chen, Dongping Lin, Bingshun Wang, Michael Dennis Jensen, Yingli Lu

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background & aims: Epidemiologic studies have revealed that early-life conditions influence later risk of chronic diseases. We aimed to explore whether exposure to Chinese famine between 1959 and 1962 during fetal and childhood period was related with metabolic syndrome (MS) in adulthood. Methods: 6445 subjects from SPECT-China study were divided into fetal-exposed (1959-1962), childhood-exposed (1949-1958), adolescence/young adult-exposed (1921-1948), non-exposed (1963-1974) and non-exposed (after 1975). MS was defined by the International Diabetes Federation criteria. Results: The prevalences of MS in the non-exposed (1963-1974), fetal and childhood-exposed were 16.4%, 20.1% and 19.1% in men and 13.5%, 23.7% and 33.5% in women, respectively. After adjustment for age, compared with non-exposed (1963-1974), fetal and childhood-exposed women had significantly higher prevalences of MS (P <0.05), but not in men. Famine exposure during the fetal period (OR 1.47, 95% CI 1.05, 2.07) and childhood (OR 1.80, 95% CI 1.22, 2.67) was associated with higher risk of MS in women after adjusting for age (both P <0.05). Further adjustments for age, smoking, rural/urban residence and economic status did not significantly attenuate this association. Conclusions: Exposure to famine in early life had sex-specific association with MS. It also suggests the adverse effects of malnutrition might extend beyond the 'first 1000 days' and last 9 years.

Original languageEnglish (US)
JournalClinical Nutrition
DOIs
StateAccepted/In press - Aug 14 2015

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Starvation
Single-Photon Emission-Computed Tomography
Malnutrition
Epidemiologic Studies
Young Adult
China
Chronic Disease
Smoking
Economics

Keywords

  • Early life
  • Famine
  • Metabolic syndrome
  • Sex specific

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

Cite this

Wang, N., Wang, X., Li, Q., Han, B., Chen, Y., Zhu, C., ... Lu, Y. (Accepted/In press). The famine exposure in early life and metabolic syndrome in adulthood. Clinical Nutrition. https://doi.org/10.1016/j.clnu.2015.11.010

The famine exposure in early life and metabolic syndrome in adulthood. / Wang, Ningjian; Wang, Xiaojin; Li, Qin; Han, Bing; Chen, Yi; Zhu, Chunfang; Chen, Yingchao; Lin, Dongping; Wang, Bingshun; Jensen, Michael Dennis; Lu, Yingli.

In: Clinical Nutrition, 14.08.2015.

Research output: Contribution to journalArticle

Wang, N, Wang, X, Li, Q, Han, B, Chen, Y, Zhu, C, Chen, Y, Lin, D, Wang, B, Jensen, MD & Lu, Y 2015, 'The famine exposure in early life and metabolic syndrome in adulthood', Clinical Nutrition. https://doi.org/10.1016/j.clnu.2015.11.010
Wang, Ningjian ; Wang, Xiaojin ; Li, Qin ; Han, Bing ; Chen, Yi ; Zhu, Chunfang ; Chen, Yingchao ; Lin, Dongping ; Wang, Bingshun ; Jensen, Michael Dennis ; Lu, Yingli. / The famine exposure in early life and metabolic syndrome in adulthood. In: Clinical Nutrition. 2015.
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abstract = "Background & aims: Epidemiologic studies have revealed that early-life conditions influence later risk of chronic diseases. We aimed to explore whether exposure to Chinese famine between 1959 and 1962 during fetal and childhood period was related with metabolic syndrome (MS) in adulthood. Methods: 6445 subjects from SPECT-China study were divided into fetal-exposed (1959-1962), childhood-exposed (1949-1958), adolescence/young adult-exposed (1921-1948), non-exposed (1963-1974) and non-exposed (after 1975). MS was defined by the International Diabetes Federation criteria. Results: The prevalences of MS in the non-exposed (1963-1974), fetal and childhood-exposed were 16.4{\%}, 20.1{\%} and 19.1{\%} in men and 13.5{\%}, 23.7{\%} and 33.5{\%} in women, respectively. After adjustment for age, compared with non-exposed (1963-1974), fetal and childhood-exposed women had significantly higher prevalences of MS (P <0.05), but not in men. Famine exposure during the fetal period (OR 1.47, 95{\%} CI 1.05, 2.07) and childhood (OR 1.80, 95{\%} CI 1.22, 2.67) was associated with higher risk of MS in women after adjusting for age (both P <0.05). Further adjustments for age, smoking, rural/urban residence and economic status did not significantly attenuate this association. Conclusions: Exposure to famine in early life had sex-specific association with MS. It also suggests the adverse effects of malnutrition might extend beyond the 'first 1000 days' and last 9 years.",
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AU - Zhu, Chunfang

AU - Chen, Yingchao

AU - Lin, Dongping

AU - Wang, Bingshun

AU - Jensen, Michael Dennis

AU - Lu, Yingli

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N2 - Background & aims: Epidemiologic studies have revealed that early-life conditions influence later risk of chronic diseases. We aimed to explore whether exposure to Chinese famine between 1959 and 1962 during fetal and childhood period was related with metabolic syndrome (MS) in adulthood. Methods: 6445 subjects from SPECT-China study were divided into fetal-exposed (1959-1962), childhood-exposed (1949-1958), adolescence/young adult-exposed (1921-1948), non-exposed (1963-1974) and non-exposed (after 1975). MS was defined by the International Diabetes Federation criteria. Results: The prevalences of MS in the non-exposed (1963-1974), fetal and childhood-exposed were 16.4%, 20.1% and 19.1% in men and 13.5%, 23.7% and 33.5% in women, respectively. After adjustment for age, compared with non-exposed (1963-1974), fetal and childhood-exposed women had significantly higher prevalences of MS (P <0.05), but not in men. Famine exposure during the fetal period (OR 1.47, 95% CI 1.05, 2.07) and childhood (OR 1.80, 95% CI 1.22, 2.67) was associated with higher risk of MS in women after adjusting for age (both P <0.05). Further adjustments for age, smoking, rural/urban residence and economic status did not significantly attenuate this association. Conclusions: Exposure to famine in early life had sex-specific association with MS. It also suggests the adverse effects of malnutrition might extend beyond the 'first 1000 days' and last 9 years.

AB - Background & aims: Epidemiologic studies have revealed that early-life conditions influence later risk of chronic diseases. We aimed to explore whether exposure to Chinese famine between 1959 and 1962 during fetal and childhood period was related with metabolic syndrome (MS) in adulthood. Methods: 6445 subjects from SPECT-China study were divided into fetal-exposed (1959-1962), childhood-exposed (1949-1958), adolescence/young adult-exposed (1921-1948), non-exposed (1963-1974) and non-exposed (after 1975). MS was defined by the International Diabetes Federation criteria. Results: The prevalences of MS in the non-exposed (1963-1974), fetal and childhood-exposed were 16.4%, 20.1% and 19.1% in men and 13.5%, 23.7% and 33.5% in women, respectively. After adjustment for age, compared with non-exposed (1963-1974), fetal and childhood-exposed women had significantly higher prevalences of MS (P <0.05), but not in men. Famine exposure during the fetal period (OR 1.47, 95% CI 1.05, 2.07) and childhood (OR 1.80, 95% CI 1.22, 2.67) was associated with higher risk of MS in women after adjusting for age (both P <0.05). Further adjustments for age, smoking, rural/urban residence and economic status did not significantly attenuate this association. Conclusions: Exposure to famine in early life had sex-specific association with MS. It also suggests the adverse effects of malnutrition might extend beyond the 'first 1000 days' and last 9 years.

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