The family feud: Turning off Sp1 by Sp1-like KLF proteins

Gwen Lomberk, Raul Urrutia

Research output: Contribution to journalReview article

142 Scopus citations

Abstract

Sp1 is one of the best characterized transcriptional activators. The biological importance of Sp1 is underscored by the fact that several hundreds of genes are thought to be regulated by this protein. However, during the last 5 years, a more extended family of Sp1-like transcription factors has been identified and characterized by the presence of a conserved DNA-binding domain comprising three Krüppel-like zinc fingers. Each distinct family member differs in its ability to regulate transcription, and, as a consequence, to influence cellular processes. Specific activation and repression domains located within the N-terminal regions of these proteins are responsible for these differences by facilitating interactions with various co-activators and co-repressors. The present review primarily focuses on discussing the structural, biochemical and biological functions of the repressor members of this family of transcription factors. The existence of these transcriptional repressors provides a tightly regulated mechanism for silencing a large number of genes that are already known to be activated by Sp1.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalBiochemical Journal
Volume392
Issue number1
DOIs
StatePublished - Nov 15 2005

Keywords

  • Co-repressor
  • Gene regulation
  • Krüppel-like factor (KLF)
  • Sp1
  • Transcription factor
  • Zinc-finger domain

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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