TY - JOUR
T1 - The Ezh2 methyltransferase complex
T2 - Actin up in the cytosol
AU - Nolz, Jeffrey C.
AU - Gomez, Timothy S.
AU - Billadeau, Daniel D.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2005/10
Y1 - 2005/10
N2 - Ezh2, a polycomb group protein, is known to function in histone methylation, thereby regulating gene expression. However, in a recent study by Su et al., the Ezh2-containing complex has been given an additional role in cellular regulation. Cytosolic Ezh2 methyltransferase complexes were shown to associate with Vav1 and control receptor-induced actin polymerization and proliferation in a methylation-dependent manner. Overall, these findings implicate lysine methylation as a posttranslational modification crucial for receptor-mediated signal transduction events.
AB - Ezh2, a polycomb group protein, is known to function in histone methylation, thereby regulating gene expression. However, in a recent study by Su et al., the Ezh2-containing complex has been given an additional role in cellular regulation. Cytosolic Ezh2 methyltransferase complexes were shown to associate with Vav1 and control receptor-induced actin polymerization and proliferation in a methylation-dependent manner. Overall, these findings implicate lysine methylation as a posttranslational modification crucial for receptor-mediated signal transduction events.
UR - http://www.scopus.com/inward/record.url?scp=25844461464&partnerID=8YFLogxK
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U2 - 10.1016/j.tcb.2005.08.003
DO - 10.1016/j.tcb.2005.08.003
M3 - Short survey
C2 - 16126384
AN - SCOPUS:25844461464
SN - 0962-8924
VL - 15
SP - 514
EP - 517
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 10
ER -