The Ezh2 methyltransferase complex: Actin up in the cytosol

Jeffrey C. Nolz, Timothy S. Gomez, Daniel D Billadeau

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Ezh2, a polycomb group protein, is known to function in histone methylation, thereby regulating gene expression. However, in a recent study by Su et al., the Ezh2-containing complex has been given an additional role in cellular regulation. Cytosolic Ezh2 methyltransferase complexes were shown to associate with Vav1 and control receptor-induced actin polymerization and proliferation in a methylation-dependent manner. Overall, these findings implicate lysine methylation as a posttranslational modification crucial for receptor-mediated signal transduction events.

Original languageEnglish (US)
Pages (from-to)514-517
Number of pages4
JournalTrends in Cell Biology
Volume15
Issue number10
DOIs
StatePublished - Oct 2005

Fingerprint

Methyltransferases
Cytosol
Methylation
Actins
Polycomb-Group Proteins
Post Translational Protein Processing
Polymerization
Histones
Lysine
Signal Transduction
Gene Expression

ASJC Scopus subject areas

  • Cell Biology

Cite this

The Ezh2 methyltransferase complex : Actin up in the cytosol. / Nolz, Jeffrey C.; Gomez, Timothy S.; Billadeau, Daniel D.

In: Trends in Cell Biology, Vol. 15, No. 10, 10.2005, p. 514-517.

Research output: Contribution to journalArticle

Nolz, Jeffrey C. ; Gomez, Timothy S. ; Billadeau, Daniel D. / The Ezh2 methyltransferase complex : Actin up in the cytosol. In: Trends in Cell Biology. 2005 ; Vol. 15, No. 10. pp. 514-517.
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