TY - JOUR
T1 - The expression ratio of Map7/B2M is prognostic for survival in patients with stage II colon cancer
AU - Blum, Craig
AU - Graham, Amanda
AU - Yousefzadeh, Matt
AU - Shrout, Jessica
AU - Benjamin, Katie
AU - Krishna, Murli
AU - Hoda, Raza
AU - Hoda, Rana
AU - Cole, David J.
AU - Garrett-Mayer, Elizabeth
AU - Reed, Carolyn
AU - Wallace, Michael
AU - Mitas, Michael
PY - 2008/9
Y1 - 2008/9
N2 - Colorectal cancer (CRC) is the second most frequent cause of cancer-related death in the United States. To determine whether certain molecular markers might be prognostic for survival, we measured by quantitative real-time RT-PCR the expression levels of 15 previously studied genes that are known to be up-regulated or down-regulated in the progression of epithelial cancers. The tumor samples were extracted from formalin-fixed paraffin-embedded primary tissues derived from patients with Stage II CRC who developed disease recurrence within two years (n=10), or were disease-free for at least 4 years (n=12). We were able to determine, by AUC curve analysis, that the ratio of microtubule associated protein 7 (Map7)/B2M was predictive of outcome in our sample set. Further, using Kaplan-Meier survival analysis, we observed significantly different curves as a function of marker positivity for the Map7/B2M (p=0.0001; HR= 11) expression ratio. This suggests that the expression ratio of Map7/B2M may serve as a valuable prognostic marker in patients with Stage II colon cancer, and potentially guide therapeutic decision making.
AB - Colorectal cancer (CRC) is the second most frequent cause of cancer-related death in the United States. To determine whether certain molecular markers might be prognostic for survival, we measured by quantitative real-time RT-PCR the expression levels of 15 previously studied genes that are known to be up-regulated or down-regulated in the progression of epithelial cancers. The tumor samples were extracted from formalin-fixed paraffin-embedded primary tissues derived from patients with Stage II CRC who developed disease recurrence within two years (n=10), or were disease-free for at least 4 years (n=12). We were able to determine, by AUC curve analysis, that the ratio of microtubule associated protein 7 (Map7)/B2M was predictive of outcome in our sample set. Further, using Kaplan-Meier survival analysis, we observed significantly different curves as a function of marker positivity for the Map7/B2M (p=0.0001; HR= 11) expression ratio. This suggests that the expression ratio of Map7/B2M may serve as a valuable prognostic marker in patients with Stage II colon cancer, and potentially guide therapeutic decision making.
KW - Colon cancer
KW - Map7/B2M
UR - http://www.scopus.com/inward/record.url?scp=44949117420&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44949117420&partnerID=8YFLogxK
U2 - 10.3892/ijo_00000043
DO - 10.3892/ijo_00000043
M3 - Article
C2 - 18695889
AN - SCOPUS:44949117420
SN - 1019-6439
VL - 33
SP - 579
EP - 584
JO - International journal of oncology
JF - International journal of oncology
IS - 3
ER -