The expression of the novel cytotoxic protein granzyme M by large granular lymphocytic leukaemias of both T-cell and NK-cell lineage

An unexpected finding with implications regarding the pathobiology of these disorders

William G. Morice, Dragan Jevremovic, Curtis A. Hanson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Granzyme M (GrM) is a novel cytotoxic protein normally exclusively expressed by natural killer (NK)-cells and cytotoxic T-cells with innate immune function. As most T-cell granular lymphocytic leukaemias (T-LGL) are thought to be derived from the adaptive immune system it was predicted that T-LGL would be GrM negative. Contrary to this hypothesis, bone marrow biopsy immunohistochemistry revealed that GrM was frequently expressed in both T-LGL (16 / 18) and NK-LGL (6 / 9). These unexpected results suggest commonality between T- and NK-LGL, providing further support to the notion that T-LGL is a disorder of dysregulated, chronically stimulated, adaptive cytotoxic T-cells.

Original languageEnglish (US)
Pages (from-to)237-239
Number of pages3
JournalBritish Journal of Haematology
Volume137
Issue number3
DOIs
StatePublished - May 2007

Fingerprint

Large Granular Lymphocytic Leukemia
T-Cell Leukemia
Granzymes
Cell Lineage
Natural Killer Cells
Proteins
T-Lymphocytes
Immune System
Bone Marrow
Immunohistochemistry
Biopsy

Keywords

  • Granzyme
  • Immunohistochemistry
  • Large granular lymphocytic leukaemia
  • Natural killer-cell
  • T-cell

ASJC Scopus subject areas

  • Hematology

Cite this

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