The experimental animal models for assessing treatment of restenosis

Birgit Kantor, Khalid Ashai, David R. Holmes, Robert S. Schwartz

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Coronary restenosis after percutaneous interventions remains a major clinical problem. The assessment of therapies for the prevention of restenosis relies on the use of experimental models. This review describes the most frequently used animal models of coronary artery retenosis and the intraspecies differences among them, particularly in the extent and composition of the neointimal thickening. These differences in neointima formation should be considered in the interpretation of effective antiproliferative therapies before they are transferred into clinical trials.

Original languageEnglish (US)
Pages (from-to)48-54
Number of pages7
JournalCardiovascular Radiation Medicine
Volume1
Issue number1
DOIs
StatePublished - Jan 1 1999

Keywords

  • Animal models
  • Brachytherapy
  • Restenosis
  • Stents
  • Vascular biology

ASJC Scopus subject areas

  • Surgery
  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine

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