The experimental animal models for assessing treatment of restenosis

Birgit Kantor, Khalid Ashai, David R. Holmes, Robert S. Schwartz

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Coronary restenosis after percutaneous interventions remains a major clinical problem. The assessment of therapies for the prevention of restenosis relies on the use of experimental models. This review describes the most frequently used animal models of coronary artery retenosis and the intraspecies differences among them, particularly in the extent and composition of the neointimal thickening. These differences in neointima formation should be considered in the interpretation of effective antiproliferative therapies before they are transferred into clinical trials.

Original languageEnglish (US)
Pages (from-to)48-54
Number of pages7
JournalCardiovascular Radiation Medicine
Issue number1
StatePublished - Jan 1 1999


  • Animal models
  • Brachytherapy
  • Restenosis
  • Stents
  • Vascular biology

ASJC Scopus subject areas

  • Surgery
  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine

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