The evolution of stereotactic radiosurgery in neurosurgical practice

Daniel M. Trifiletti, Henry Ruiz-Garcia, Alfredo Quinones-Hinojosa, Rohan Ramakrishna, Jason P. Sheehan

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Introduction: Stereotactic radiosurgery (SRS) was born in an attempt to treat complex intracranial pathologies in a fashion whereby open surgery would create unnecessary or excessive risk. To create this innovation, it was necessary to harness advances in other fields such as engineering, physics, radiology, and computer science. Methods: We review the history of SRS to provide context to today’s current state, as well as guide future advancement in the field. Results: Since time of Lars Leksell, the young Swedish neurosurgeon who pioneered the development of the SRS, the collegial and essential partnership between neurosurgeons, radiation oncologists and physicists has given rise to radiosurgery as a prominent and successful tool in neurosurgical practice. Conclusion: We examine how neurosurgeons have helped foster the SRS evolution and how this evolution has impacted neurosurgical practice as well as that of radiation oncology and neuro-oncology.

Original languageEnglish (US)
Pages (from-to)451-459
Number of pages9
JournalJournal of neuro-oncology
Issue number3
StatePublished - Feb 2021


  • Gamma knife
  • History
  • Lars leksell
  • Neurosurgery
  • Stereotactic radiosurgery

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research


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