The evolution and impact of sarcopenia pre- and post-liver transplantation

Rahima A. Bhanji, Naoki M Takahashi, Michael R. Moynagh, Praveena Narayanan, Mounika Angirekula, Kristin C. Mara, Ross A. Dierkhising, Kymberly D. Watt

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: Sarcopenia is associated with both increased wait-list mortality and mortality following liver transplantation. Aims: To determine the course of sarcopenia from transplant evaluation until 1 year post-transplant, and its implications on hospitalisation and mortality following liver transplantation. Methods: Two hundred and ninety-three transplant recipients from 2002 to 2006 had pre-transplant CT scans analysed at the third lumbar region for sarcopenia, myosteatosis and abdominal visceral fat content. Half the recipients had post-transplant CT scan for interpretation (161/293). Results: Sarcopenia was present in 146/293 (50%) of the patients pre-transplant. There was a significant decrease in muscle mass (loss 2.0 ± 4.9 cm 2 /m 2 ; P < 0.001), and an increase in myosteatosis while awaiting liver transplantation. There was no significant change in abdominal visceral fat. For every 1 cm 2 /m 2 decrease in muscle mass there was an increase in post-transplant length of stay by 0.36 days (P = 0.005). Post-transplant, 98/161 (61%) of patients with CT imaging had sarcopenia (25 de novo and 73 persistent), with continued increase in myosteatosis, lower Hounsfield units (−5.0 [IQR −8.6 to 0.1]; P < 0.001) and an increase in abdominal visceral fat (4.9 [IQR −4.4 to 15.6] cm 2 /m 2 ; P < 0.001). There was no statistically significant difference in 1-year mortality in patients with de novo sarcopenia compared to patients with sarcopenia both pre- and post-transplant (HR 1.88; P = 0.088). Conclusions: Sarcopenia progresses up to 1 year following liver transplantation and is associated with an increase in post-transplant length of stay.

Original languageEnglish (US)
Pages (from-to)807-813
Number of pages7
JournalAlimentary Pharmacology and Therapeutics
Volume49
Issue number6
DOIs
StatePublished - Mar 1 2019

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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    Bhanji, R. A., Takahashi, N. M., Moynagh, M. R., Narayanan, P., Angirekula, M., Mara, K. C., Dierkhising, R. A., & Watt, K. D. (2019). The evolution and impact of sarcopenia pre- and post-liver transplantation. Alimentary Pharmacology and Therapeutics, 49(6), 807-813. https://doi.org/10.1111/apt.15161