The etiopathogenesis of Parkinson disease and suggestions for future research. Part I

Irene Litvan; Glenda Halliday; Mark Hallett; Christopher G. Goetz; Walter Rocca; Charles Duyckaerts; Yoav Ben-Shlomo; Dennis W. Dickson; Anthony E. Lang; Marie Francoise Chesselet; William J. Langston; Donato A. Di Monte; Thomas Gasser; Theo Hagg; John Hardy; Peter Jenner; Eldad Melamed; Richard H. Myers; Davis Parker; Donald L. Price

doi:10.1097/nen.0b013e3180415e42

The etiopathogenesis of Parkinson disease and suggestions for future research. Part I

Irene Litvan, Glenda Halliday, Mark Hallett, Christopher G. Goetz, Walter Rocca, Charles Duyckaerts, Yoav Ben-Shlomo, Dennis W. Dickson, Anthony E. Lang, Marie Francoise Chesselet, William J. Langston, Donato A. Di Monte, Thomas Gasser, Theo Hagg, John Hardy, Peter Jenner, Eldad Melamed, Richard H. Myers, Davis Parker, Donald L. Price

Research output: Contribution to journal › Review article › peer-review

89 Scopus citations

Abstract

We are at a critical juncture in our knowledge of the etiology and pathogenesis of Parkinson disease (PD). It is clear that PD is not a single entity simply resulting from a dopaminergic deficit; rather it is most likely caused by a combination of genetic and environmental factors and, although there is extensive new information on the etiology and pathogenesis of PD that may advance its treatment, new syntheses of this information are needed. The first part of this two-part, state-of-the-art review by leaders in Parkinson research critically examines the field to identify where new knowledge and ideas might be helpful for treatment purposes. Topics reviewed in Part I include the definition of the disease, neuropathologic contributions, and epidemiologic, environmental, and demographic issues.

Original language	English (US)
Pages (from-to)	251-257
Number of pages	7
Journal	Journal of Neuropathology and Experimental Neurology
Volume	66
Issue number	4
DOIs	https://doi.org/10.1097/nen.0b013e3180415e42
State	Published - Apr 2007

Keywords

Lewy bodies
Parkinson disease
Synucleinopathies

ASJC Scopus subject areas

Pathology and Forensic Medicine
Neurology
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1097/nen.0b013e3180415e42

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Litvan, I., Halliday, G., Hallett, M., Goetz, C. G., Rocca, W., Duyckaerts, C., Ben-Shlomo, Y., Dickson, D. W., Lang, A. E., Chesselet, M. F., Langston, W. J., Di Monte, D. A., Gasser, T., Hagg, T., Hardy, J., Jenner, P., Melamed, E., Myers, R. H., Parker, D., & Price, D. L. (2007). The etiopathogenesis of Parkinson disease and suggestions for future research. Part I. Journal of Neuropathology and Experimental Neurology, 66(4), 251-257. https://doi.org/10.1097/nen.0b013e3180415e42

Litvan, I, Halliday, G, Hallett, M, Goetz, CG, Rocca, W, Duyckaerts, C, Ben-Shlomo, Y, Dickson, DW, Lang, AE, Chesselet, MF, Langston, WJ, Di Monte, DA, Gasser, T, Hagg, T, Hardy, J, Jenner, P, Melamed, E, Myers, RH, Parker, D & Price, DL 2007, 'The etiopathogenesis of Parkinson disease and suggestions for future research. Part I', Journal of Neuropathology and Experimental Neurology, vol. 66, no. 4, pp. 251-257. https://doi.org/10.1097/nen.0b013e3180415e42

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abstract = "We are at a critical juncture in our knowledge of the etiology and pathogenesis of Parkinson disease (PD). It is clear that PD is not a single entity simply resulting from a dopaminergic deficit; rather it is most likely caused by a combination of genetic and environmental factors and, although there is extensive new information on the etiology and pathogenesis of PD that may advance its treatment, new syntheses of this information are needed. The first part of this two-part, state-of-the-art review by leaders in Parkinson research critically examines the field to identify where new knowledge and ideas might be helpful for treatment purposes. Topics reviewed in Part I include the definition of the disease, neuropathologic contributions, and epidemiologic, environmental, and demographic issues.",

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The etiopathogenesis of Parkinson disease and suggestions for future research. Part I

Abstract

Keywords

ASJC Scopus subject areas

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