The etiology of Alzheimer's disease

epidemiologic contributions with emphasis on the genetic hypothesis.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This report reviews the contributions of analytic epidemiology to the generation and testing of etiologic hypotheses for clinically diagnosed Alzheimer's disease (AD). Because AD can be diagnosed with certainty only at autopsy, currently available epidemiologic data are often based on a presumed clinical diagnosis. Several case-control studies have shown that cases of either dementia or Down's syndrome in other family members, advanced age of the mother at subject's birth, and head injury are possible risk factors. Many other factors have been investigated but were not found to be consistently associated.

Original languageEnglish (US)
Pages (from-to)3-12
Number of pages10
JournalJournal of Neural Transmission, Supplement
Volume24
StatePublished - 1987
Externally publishedYes

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Alzheimer Disease
Birth Injuries
Down Syndrome
Craniocerebral Trauma
Dementia
Case-Control Studies
Autopsy
Epidemiology
Mothers

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "The etiology of Alzheimer's disease: epidemiologic contributions with emphasis on the genetic hypothesis.",
abstract = "This report reviews the contributions of analytic epidemiology to the generation and testing of etiologic hypotheses for clinically diagnosed Alzheimer's disease (AD). Because AD can be diagnosed with certainty only at autopsy, currently available epidemiologic data are often based on a presumed clinical diagnosis. Several case-control studies have shown that cases of either dementia or Down's syndrome in other family members, advanced age of the mother at subject's birth, and head injury are possible risk factors. Many other factors have been investigated but were not found to be consistently associated.",
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journal = "Journal of Neural Transmission, Supplement",
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AB - This report reviews the contributions of analytic epidemiology to the generation and testing of etiologic hypotheses for clinically diagnosed Alzheimer's disease (AD). Because AD can be diagnosed with certainty only at autopsy, currently available epidemiologic data are often based on a presumed clinical diagnosis. Several case-control studies have shown that cases of either dementia or Down's syndrome in other family members, advanced age of the mother at subject's birth, and head injury are possible risk factors. Many other factors have been investigated but were not found to be consistently associated.

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