The epidemiology of venous thromboembolism in the community

J. A. Heit, M. D. Silverstein, D. N. Mohr, T. M. Petterson, C. M. Lohse, W. M. O'Fallon, L. J. Melton

Research output: Contribution to journalArticle

477 Citations (Scopus)

Abstract

The incidence of venous thromboembolism exceeds 1 per 1000; over 200,000 new cases occur in the United States annually. Of these, 30% die within 30 days; one-fifth suffer sudden death due to pulmonary embolism. Despite improved prophylaxis, the incidence of venous thromboembolism has been constant since 1980. Independent risk factors for venous thromboembolism include increasing age, male gender, surgery, trauma, hospital or nursing home confinement, malignancy, neurologic disease with extremity paresis, central venous catheter/transvenous pacemaker, prior superficial vein thrombosis, and varicose veins; among women, risk factors include pregnancy, oral contraceptives, and hormone replacement therapy. About 30% of surviving cases develop recurrent venous thromboembolism within ten years. Independent predictors for recurrence include increasing age, obesity, malignant neoplasm, and extremity paresis. About 28% of cases develop venous stasis syndrome within 20 years. To reduce venous thromboembolism incidence, improve survival, and prevent recurrence and complications, patients with these characteristics should receive appropriate prophylaxis.

Original languageEnglish (US)
Pages (from-to)452-463
Number of pages12
JournalThrombosis and Haemostasis
Volume86
Issue number1
StatePublished - 2001

Fingerprint

Venous Thromboembolism
Epidemiology
Paresis
Incidence
Extremities
Postthrombotic Syndrome
Recurrence
Central Venous Catheters
Hormone Replacement Therapy
Varicose Veins
Oral Contraceptives
Sudden Death
Nursing Homes
Nervous System Diseases
Pulmonary Embolism
Veins
Neoplasms
Thrombosis
Obesity
Pregnancy

Keywords

  • Deep vein thrombosis
  • Epidemiology
  • Pulmonary embolism
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology

Cite this

Heit, J. A., Silverstein, M. D., Mohr, D. N., Petterson, T. M., Lohse, C. M., O'Fallon, W. M., & Melton, L. J. (2001). The epidemiology of venous thromboembolism in the community. Thrombosis and Haemostasis, 86(1), 452-463.

The epidemiology of venous thromboembolism in the community. / Heit, J. A.; Silverstein, M. D.; Mohr, D. N.; Petterson, T. M.; Lohse, C. M.; O'Fallon, W. M.; Melton, L. J.

In: Thrombosis and Haemostasis, Vol. 86, No. 1, 2001, p. 452-463.

Research output: Contribution to journalArticle

Heit, JA, Silverstein, MD, Mohr, DN, Petterson, TM, Lohse, CM, O'Fallon, WM & Melton, LJ 2001, 'The epidemiology of venous thromboembolism in the community', Thrombosis and Haemostasis, vol. 86, no. 1, pp. 452-463.
Heit JA, Silverstein MD, Mohr DN, Petterson TM, Lohse CM, O'Fallon WM et al. The epidemiology of venous thromboembolism in the community. Thrombosis and Haemostasis. 2001;86(1):452-463.
Heit, J. A. ; Silverstein, M. D. ; Mohr, D. N. ; Petterson, T. M. ; Lohse, C. M. ; O'Fallon, W. M. ; Melton, L. J. / The epidemiology of venous thromboembolism in the community. In: Thrombosis and Haemostasis. 2001 ; Vol. 86, No. 1. pp. 452-463.
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