TY - JOUR
T1 - The Epidemiology of Microscopic Colitis in Olmsted County, Minnesota
T2 - Population-Based Study From 2011 to 2019
AU - Tome, June
AU - Sehgal, Kanika
AU - Kamboj, Amrit K.
AU - Harmsen, William S.
AU - Kammer, Patricia P.
AU - Loftus, Edward V.
AU - Tremaine, William J.
AU - Khanna, Sahil
AU - Pardi, Darrell S.
N1 - Funding Information:
Funding This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health ( R01AG034676 ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2022 AGA Institute
PY - 2022/5
Y1 - 2022/5
N2 - Background & Aims: Epidemiologic studies from Europe and North America have reported an increasing incidence of microscopic colitis (MC) in the late 20th century, followed by a plateau. This population-based study assessed recent incidence trends and the overall prevalence of MC over the past decade. Methods: Residents of Olmsted County, MN, diagnosed with collagenous colitis (CC) or lymphocytic colitis (LC) between January 1, 2011, and December 31, 2019 were identified using the Rochester Epidemiology Project. Clinical variables were abstracted by chart review. Incidence rates were age- and sex-adjusted to the 2010 US population. Associations between incidence and age, sex, and calendar periods were evaluated using Poisson regression analyses. Results: A total of 268 incident cases of MC were identified with a median age at diagnosis of 64 years (range, 19–90 y); 207 (77%) were women. The age- and sex-adjusted incidence of MC was 25.8 (95% CI, 22.7–28.9) cases per 100,000 person-years. The incidence of LC was 15.8 (95% CI, 13.4–18.2) and CC was 9.9 (95% CI, 8.1–11.9) per 100,000 person-years. A higher MC incidence was associated with increasing age and female sex (P <.01). There was no significant trend in age- and sex-adjusted incidence rate over the study period (P =.92). On December 31, 2019, the prevalence of MC, LC, and CC (including cases diagnosed before 2011) was 246.2, 146.1, and 100.1 per 100,000 persons, respectively. Conclusions: The incidence of MC and its subtypes was stable between 2011 and 2019, but its prevalence was higher than in previous periods. The incidence of MC continues to be associated with increasing age and female sex.
AB - Background & Aims: Epidemiologic studies from Europe and North America have reported an increasing incidence of microscopic colitis (MC) in the late 20th century, followed by a plateau. This population-based study assessed recent incidence trends and the overall prevalence of MC over the past decade. Methods: Residents of Olmsted County, MN, diagnosed with collagenous colitis (CC) or lymphocytic colitis (LC) between January 1, 2011, and December 31, 2019 were identified using the Rochester Epidemiology Project. Clinical variables were abstracted by chart review. Incidence rates were age- and sex-adjusted to the 2010 US population. Associations between incidence and age, sex, and calendar periods were evaluated using Poisson regression analyses. Results: A total of 268 incident cases of MC were identified with a median age at diagnosis of 64 years (range, 19–90 y); 207 (77%) were women. The age- and sex-adjusted incidence of MC was 25.8 (95% CI, 22.7–28.9) cases per 100,000 person-years. The incidence of LC was 15.8 (95% CI, 13.4–18.2) and CC was 9.9 (95% CI, 8.1–11.9) per 100,000 person-years. A higher MC incidence was associated with increasing age and female sex (P <.01). There was no significant trend in age- and sex-adjusted incidence rate over the study period (P =.92). On December 31, 2019, the prevalence of MC, LC, and CC (including cases diagnosed before 2011) was 246.2, 146.1, and 100.1 per 100,000 persons, respectively. Conclusions: The incidence of MC and its subtypes was stable between 2011 and 2019, but its prevalence was higher than in previous periods. The incidence of MC continues to be associated with increasing age and female sex.
KW - Collagenous Colitis
KW - Epidemiology
KW - Incidence
KW - Lymphocytic Colitis
KW - Microscopic Colitis
KW - Prevalence
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U2 - 10.1016/j.cgh.2021.06.027
DO - 10.1016/j.cgh.2021.06.027
M3 - Article
C2 - 34216819
AN - SCOPUS:85111612139
SN - 1542-3565
VL - 20
SP - 1085
EP - 1094
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 5
ER -