The epidemiology of Alzheimer's disease: Laying the foundation for drug design, conduct, and analysis of clinical trials

Kristine Yaffe, Michael Tocco, Ronald C. Petersen, Catherine Sigler, Leah C. Burns, Christel Cornelius, Ara S. Khachaturian, Michael C. Irizarry, Maria C. Carrillo

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Epidemiological studies increasingly inform Alzheimer's disease (AD) public health impact, prevention strategies, drug targets, therapeutic interventions, and clinical trial design. For this reason, the Alzheimer's Association Research Roundtable convened an international group of AD experts with experience in conducting both observational and clinical trials for a meeting on October 19 and 20, 2010, in Washington, DC, to discuss the role of epidemiologic studies in AD research and therapeutic advances. Topics included wellness markers and risk factors, with a focus on special populations such as those at elevated risk, super agers, and underserved populations. Discussions also highlighted lessons learned from observational studies of aging, cardiovascular disease, and other disease areas, as well as how new technologies have enabled the gathering of data relevant to drug development and clinical trial conduct.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalAlzheimer's and Dementia
Volume8
Issue number3
DOIs
StatePublished - May 1 2012

Keywords

  • Aging
  • Alzheimer's disease
  • Dementia
  • Epidemiology
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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    Yaffe, K., Tocco, M., Petersen, R. C., Sigler, C., Burns, L. C., Cornelius, C., Khachaturian, A. S., Irizarry, M. C., & Carrillo, M. C. (2012). The epidemiology of Alzheimer's disease: Laying the foundation for drug design, conduct, and analysis of clinical trials. Alzheimer's and Dementia, 8(3), 237-242. https://doi.org/10.1016/j.jalz.2011.12.005