The enteric microbiome in hepatobiliary health and disease

James H. Tabibian, Cyril Varghese, Nicholas F. Larusso, Steven P. O'Hara

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Increasing evidence points to the contribution of the intestinal microbiome as a potentially key determinant in the initiation and/or progression of hepatobiliary disease. While current understanding of this dynamic is incomplete, exciting insights are continually being made and more are expected given the developments in molecular and high-throughput omics techniques. In this brief review, we provide a practical and updated synopsis of the interaction of the intestinal microbiome with the liver and its downstream impact on the initiation, progression and complications of hepatobiliary disease.

Original languageEnglish (US)
Pages (from-to)480-487
Number of pages8
JournalLiver International
Volume36
Issue number4
DOIs
StatePublished - Apr 1 2016

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Keywords

  • Cholangiopathies
  • Cirrhosis
  • Liver diseases
  • Microbiota
  • Toll-like receptors

ASJC Scopus subject areas

  • Hepatology

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