The enteric microbiome in hepatobiliary health and disease

James H. Tabibian; Cyril Varghese; Nicholas F. Larusso; Steven P. O'Hara

doi:10.1111/liv.13009

The enteric microbiome in hepatobiliary health and disease

James H. Tabibian, Cyril Varghese, Nicholas F. Larusso, Steven P. O'Hara

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Increasing evidence points to the contribution of the intestinal microbiome as a potentially key determinant in the initiation and/or progression of hepatobiliary disease. While current understanding of this dynamic is incomplete, exciting insights are continually being made and more are expected given the developments in molecular and high-throughput omics techniques. In this brief review, we provide a practical and updated synopsis of the interaction of the intestinal microbiome with the liver and its downstream impact on the initiation, progression and complications of hepatobiliary disease.

Original language	English (US)
Pages (from-to)	480-487
Number of pages	8
Journal	Liver International
Volume	36
Issue number	4
DOIs	https://doi.org/10.1111/liv.13009
State	Published - Apr 1 2016

Keywords

Cholangiopathies
Cirrhosis
Liver diseases
Microbiota
Toll-like receptors

ASJC Scopus subject areas

Hepatology

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10.1111/liv.13009

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title = "The enteric microbiome in hepatobiliary health and disease",

abstract = "Increasing evidence points to the contribution of the intestinal microbiome as a potentially key determinant in the initiation and/or progression of hepatobiliary disease. While current understanding of this dynamic is incomplete, exciting insights are continually being made and more are expected given the developments in molecular and high-throughput omics techniques. In this brief review, we provide a practical and updated synopsis of the interaction of the intestinal microbiome with the liver and its downstream impact on the initiation, progression and complications of hepatobiliary disease.",

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AU - Larusso, Nicholas F.

AU - O'Hara, Steven P.

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AB - Increasing evidence points to the contribution of the intestinal microbiome as a potentially key determinant in the initiation and/or progression of hepatobiliary disease. While current understanding of this dynamic is incomplete, exciting insights are continually being made and more are expected given the developments in molecular and high-throughput omics techniques. In this brief review, we provide a practical and updated synopsis of the interaction of the intestinal microbiome with the liver and its downstream impact on the initiation, progression and complications of hepatobiliary disease.

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KW - Cirrhosis

KW - Liver diseases

KW - Microbiota

KW - Toll-like receptors

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The enteric microbiome in hepatobiliary health and disease

Abstract

Keywords

ASJC Scopus subject areas

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