The ensemble male hypothalamo-pituitary-gonadal axis

Johannes D Veldhuis, Daniel M. Keenan, Ali Iranmanesh, Paul Y Takahashi, Ajay Nehra

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Citations (Scopus)

Abstract

Healthy aging in men progressively reduces testosterone availability to bone, muscle, brain, fat depots, immune tissue, and sexual organs (1). Free and bioavailable testosterone concentrations fall by 0.8% to 1.5% per year and are reduced by 30% by the seventh compared with third decade of life. Sexhormone binding globulin (SHBG) concentrations rise twofold in older males. Estradiol bioavailability declines along with that of testosterone, probably contributing to reduced bone density, elevated follicle-stimulating hormone (FSH) concentrations, and decreased prolactin concentrations. Although testis size and firmness diminish, spermatogenesis may be relatively preserved in elderly men.

Original languageEnglish (US)
Title of host publicationPhysiological Basis of Aging and Geriatrics, Fourth Edition
PublisherCRC Press
Pages185-203
Number of pages19
ISBN (Electronic)9781420007091
ISBN (Print)9780849373053
StatePublished - Jan 1 2007

Fingerprint

Testosterone
Bone
Globulins
Follicle Stimulating Hormone
Spermatogenesis
Prolactin
Bone Density
Biological Availability
Muscle
Testis
Estradiol
Brain
Aging of materials
Fats
Availability
Tissue
Bone and Bones
Muscles

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Veldhuis, J. D., Keenan, D. M., Iranmanesh, A., Takahashi, P. Y., & Nehra, A. (2007). The ensemble male hypothalamo-pituitary-gonadal axis. In Physiological Basis of Aging and Geriatrics, Fourth Edition (pp. 185-203). CRC Press.

The ensemble male hypothalamo-pituitary-gonadal axis. / Veldhuis, Johannes D; Keenan, Daniel M.; Iranmanesh, Ali; Takahashi, Paul Y; Nehra, Ajay.

Physiological Basis of Aging and Geriatrics, Fourth Edition. CRC Press, 2007. p. 185-203.

Research output: Chapter in Book/Report/Conference proceedingChapter

Veldhuis, JD, Keenan, DM, Iranmanesh, A, Takahashi, PY & Nehra, A 2007, The ensemble male hypothalamo-pituitary-gonadal axis. in Physiological Basis of Aging and Geriatrics, Fourth Edition. CRC Press, pp. 185-203.
Veldhuis JD, Keenan DM, Iranmanesh A, Takahashi PY, Nehra A. The ensemble male hypothalamo-pituitary-gonadal axis. In Physiological Basis of Aging and Geriatrics, Fourth Edition. CRC Press. 2007. p. 185-203
Veldhuis, Johannes D ; Keenan, Daniel M. ; Iranmanesh, Ali ; Takahashi, Paul Y ; Nehra, Ajay. / The ensemble male hypothalamo-pituitary-gonadal axis. Physiological Basis of Aging and Geriatrics, Fourth Edition. CRC Press, 2007. pp. 185-203
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