The enigmatic role of H2Bub1 in cancer

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

The post-translational modification of histone proteins plays an important role in controlling cell fate by directing essentially all DNA-associated nuclear processes. Misregulation and mutation of histone modifying enzymes is a hallmark of tumorigenesis. However, how these different epigenetic modifications lead to tumor initiation and/or progression remains poorly understood. Recent studies have uncovered a potential tumor suppressor role for histone H2B monoubiquitination (H2Bub1). Like many other histone modifications, H2Bub1 has diverse functions and plays roles both in transcriptional activation and repression as well as in controlling mRNA processing and directing DNA repair processes. Notably, H2Bub1 has been linked to transcriptional elongation and is preferentially found in the transcribed region of active genes. Its activity is intimately connected to active transcription and the transcriptional elongation regulatory protein cyclin-dependent kinase-9 (CDK9) and the facilitates chromatin transcription (FACT) complex. This review provides an overview of the current understanding of H2Bub1 function in mammalian systems with a particular emphasis on its role in cancer and potential options for exploiting this knowledge for the treatment of cancer.

Original languageEnglish (US)
Pages (from-to)1592-1601
Number of pages10
JournalFEBS Letters
Volume586
Issue number11
DOIs
StatePublished - Jun 4 2012
Externally publishedYes

Fingerprint

Histones
Transcription
Tumors
Cyclin-Dependent Kinase 9
Elongation
Neoplasms
Histone Code
DNA
Post Translational Protein Processing
Epigenomics
DNA Repair
Transcriptional Activation
Chromatin
Carcinogenesis
Repair
Genes
Chemical activation
Proteins
Messenger RNA
Mutation

Keywords

  • Cancer
  • Chromatin
  • Epigenetic
  • H2B
  • Monoubiquitination
  • Tumor suppressor

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

The enigmatic role of H2Bub1 in cancer. / Johnsen, Steven.

In: FEBS Letters, Vol. 586, No. 11, 04.06.2012, p. 1592-1601.

Research output: Contribution to journalReview article

Johnsen, Steven. / The enigmatic role of H2Bub1 in cancer. In: FEBS Letters. 2012 ; Vol. 586, No. 11. pp. 1592-1601.
@article{fbb3d5b64fe449ac8552c1d8b142a5b1,
title = "The enigmatic role of H2Bub1 in cancer",
abstract = "The post-translational modification of histone proteins plays an important role in controlling cell fate by directing essentially all DNA-associated nuclear processes. Misregulation and mutation of histone modifying enzymes is a hallmark of tumorigenesis. However, how these different epigenetic modifications lead to tumor initiation and/or progression remains poorly understood. Recent studies have uncovered a potential tumor suppressor role for histone H2B monoubiquitination (H2Bub1). Like many other histone modifications, H2Bub1 has diverse functions and plays roles both in transcriptional activation and repression as well as in controlling mRNA processing and directing DNA repair processes. Notably, H2Bub1 has been linked to transcriptional elongation and is preferentially found in the transcribed region of active genes. Its activity is intimately connected to active transcription and the transcriptional elongation regulatory protein cyclin-dependent kinase-9 (CDK9) and the facilitates chromatin transcription (FACT) complex. This review provides an overview of the current understanding of H2Bub1 function in mammalian systems with a particular emphasis on its role in cancer and potential options for exploiting this knowledge for the treatment of cancer.",
keywords = "Cancer, Chromatin, Epigenetic, H2B, Monoubiquitination, Tumor suppressor",
author = "Steven Johnsen",
year = "2012",
month = "6",
day = "4",
doi = "10.1016/j.febslet.2012.04.002",
language = "English (US)",
volume = "586",
pages = "1592--1601",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "11",

}

TY - JOUR

T1 - The enigmatic role of H2Bub1 in cancer

AU - Johnsen, Steven

PY - 2012/6/4

Y1 - 2012/6/4

N2 - The post-translational modification of histone proteins plays an important role in controlling cell fate by directing essentially all DNA-associated nuclear processes. Misregulation and mutation of histone modifying enzymes is a hallmark of tumorigenesis. However, how these different epigenetic modifications lead to tumor initiation and/or progression remains poorly understood. Recent studies have uncovered a potential tumor suppressor role for histone H2B monoubiquitination (H2Bub1). Like many other histone modifications, H2Bub1 has diverse functions and plays roles both in transcriptional activation and repression as well as in controlling mRNA processing and directing DNA repair processes. Notably, H2Bub1 has been linked to transcriptional elongation and is preferentially found in the transcribed region of active genes. Its activity is intimately connected to active transcription and the transcriptional elongation regulatory protein cyclin-dependent kinase-9 (CDK9) and the facilitates chromatin transcription (FACT) complex. This review provides an overview of the current understanding of H2Bub1 function in mammalian systems with a particular emphasis on its role in cancer and potential options for exploiting this knowledge for the treatment of cancer.

AB - The post-translational modification of histone proteins plays an important role in controlling cell fate by directing essentially all DNA-associated nuclear processes. Misregulation and mutation of histone modifying enzymes is a hallmark of tumorigenesis. However, how these different epigenetic modifications lead to tumor initiation and/or progression remains poorly understood. Recent studies have uncovered a potential tumor suppressor role for histone H2B monoubiquitination (H2Bub1). Like many other histone modifications, H2Bub1 has diverse functions and plays roles both in transcriptional activation and repression as well as in controlling mRNA processing and directing DNA repair processes. Notably, H2Bub1 has been linked to transcriptional elongation and is preferentially found in the transcribed region of active genes. Its activity is intimately connected to active transcription and the transcriptional elongation regulatory protein cyclin-dependent kinase-9 (CDK9) and the facilitates chromatin transcription (FACT) complex. This review provides an overview of the current understanding of H2Bub1 function in mammalian systems with a particular emphasis on its role in cancer and potential options for exploiting this knowledge for the treatment of cancer.

KW - Cancer

KW - Chromatin

KW - Epigenetic

KW - H2B

KW - Monoubiquitination

KW - Tumor suppressor

UR - http://www.scopus.com/inward/record.url?scp=84861594601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861594601&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2012.04.002

DO - 10.1016/j.febslet.2012.04.002

M3 - Review article

C2 - 22564770

AN - SCOPUS:84861594601

VL - 586

SP - 1592

EP - 1601

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 11

ER -