TY - JOUR
T1 - The enigma of ectopic expression of FGFR3 in multiple myeloma
T2 - A critical initiating event or just a target for mutational activation during tumor progression
AU - Chesi, Marta
AU - Bergsagel, P. Leif
AU - Kuehl, W. Michael
PY - 2002
Y1 - 2002
N2 - The t(4;14)(pl 6.3;q32) translocation that occurs uniquely in a subset of multiple myeloma tumors results in ectopic expression of wild-type FGFR3 and enhanced expression of MMSET, a gene that is homologous to the MLL gene that is involved in acute myeloid leukemias. Wild-type FGFR3 appears to be weakly transforming in a hematopoietic murine model, whereas FGFR3 that contains kinase-activating mutations is strongly transforming in NIH3T3 cells and the hematopoietic model. The subsequent acquisition of FGFR3 kinase-activating mutations in some tumors with t(4;14) translocations confirms a role for FGFR3 in tumor progression. However, it remains to be proven if and how dysregulation of FGFR3 or MMSET mediates an early oncogenic process in multiplemyeloma.
AB - The t(4;14)(pl 6.3;q32) translocation that occurs uniquely in a subset of multiple myeloma tumors results in ectopic expression of wild-type FGFR3 and enhanced expression of MMSET, a gene that is homologous to the MLL gene that is involved in acute myeloid leukemias. Wild-type FGFR3 appears to be weakly transforming in a hematopoietic murine model, whereas FGFR3 that contains kinase-activating mutations is strongly transforming in NIH3T3 cells and the hematopoietic model. The subsequent acquisition of FGFR3 kinase-activating mutations in some tumors with t(4;14) translocations confirms a role for FGFR3 in tumor progression. However, it remains to be proven if and how dysregulation of FGFR3 or MMSET mediates an early oncogenic process in multiplemyeloma.
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U2 - 10.1097/00062752-200207000-00005
DO - 10.1097/00062752-200207000-00005
M3 - Review article
C2 - 12042702
AN - SCOPUS:0036014969
SN - 1065-6251
VL - 9
SP - 288
EP - 293
JO - Current opinion in hematology
JF - Current opinion in hematology
IS - 4
ER -