The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data

Paul M. Thompson, Jason L. Stein, Sarah E. Medland, Derrek P. Hibar, Alejandro Arias Vasquez, Miguel E. Renteria, Roberto Toro, Neda Jahanshad, Gunter Schumann, Barbara Franke, Margaret J. Wright, Nicholas G. Martin, Ingrid Agartz, Martin Alda, Saud Alhusaini, Laura Almasy, Jorge Almeida, Kathryn Alpert, Nancy C. Andreasen, Ole A. AndreassenLiana G. Apostolova, Katja Appel, Nicola J. Armstrong, Benjamin Aribisala, Mark E. Bastin, Michael Bauer, Carrie E. Bearden, Ørjan Bergmann, Elisabeth B. Binder, John Blangero, Henry J. Bockholt, Erlend Bøen, Catherine Bois, Dorret I. Boomsma, Tom Booth, Ian J. Bowman, Janita Bralten, Rachel M. Brouwer, Han G. Brunner, David G. Brohawn, Randy L. Buckner, Jan Buitelaar, Kazima Bulayeva, Juan R. Bustillo, Vince D. Calhoun, Dara M. Cannon, Rita M. Cantor, Melanie A. Carless, Xavier Caseras, Gianpiero L. Cavalleri, M. Mallar Chakravarty, Kiki D. Chang, Christopher R.K. Ching, Andrea Christoforou, Sven Cichon, Vincent P. Clark, Patricia Conrod, Giovanni Coppola, Benedicto Crespo-Facorro, Joanne E. Curran, Michael Czisch, Ian J. Deary, Eco J.C. de Geus, Anouk den Braber, Giuseppe Delvecchio, Chantal Depondt, Lieuwe de Haan, Greig I. de Zubicaray, Danai Dima, Rali Dimitrova, Srdjan Djurovic, Hongwei Dong, Gary Donohoe, Ravindranath Duggirala, Thomas D. Dyer, Stefan Ehrlich, Carl Johan Ekman, Torbjørn Elvsåshagen, Louise Emsell, Susanne Erk, Thomas Espeseth, Jesen Fagerness, Scott Fears, Iryna Fedko, Guillén Fernández, Simon E. Fisher, Tatiana Foroud, Peter T. Fox, Clyde Francks, Sophia Frangou, Eva Maria Frey, Thomas Frodl, Vincent Frouin, Hugh Garavan, Sudheer Giddaluru, David C. Glahn, Beata Godlewska, Rita Z. Goldstein, Randy L. Gollub, Hans J. Grabe, Oliver Grimm, Oliver Gruber, Tulio Guadalupe, Raquel E. Gur, Ruben C. Gur, Harald H.H. Göring, Saskia Hagenaars, Tomas Hajek, Geoffrey B. Hall, Jeremy Hall, John Hardy, Catharina A. Hartman, Johanna Hass, Sean N. Hatton, Unn K. Haukvik, Katrin Hegenscheid, Andreas Heinz, Ian B. Hickie, Beng Choon Ho, David Hoehn, Pieter J. Hoekstra, Marisa Hollinshead, Avram J. Holmes, Georg Homuth, Martine Hoogman, L. Elliot Hong, Norbert Hosten, Jouke Jan Hottenga, Hilleke E. Hulshoff Pol, Kristy S. Hwang, Clifford R. Jack, Mark Jenkinson, Caroline Johnston, Erik G. Jönsson, René S. Kahn, Dalia Kasperaviciute, Sinead Kelly, Sungeun Kim, Peter Kochunov, Laura Koenders, Bernd Krämer, John B.J. Kwok, Jim Lagopoulos, Gonzalo Laje, Mikael Landen, Bennett A. Landman, John Lauriello, Stephen M. Lawrie, Phil H. Lee, Stephanie Le Hellard, Herve Lemaître, Cassandra D. Leonardo, Chiang shan Li, Benny Liberg, David C. Liewald, Xinmin Liu, Lorna M. Lopez, Eva Loth, Anbarasu Lourdusamy, Michelle Luciano, Fabio Macciardi, Marise W.J. Machielsen, Glenda M. MacQueen, Ulrik F. Malt, René Mandl, Dara S. Manoach, Jean Luc Martinot, Mar Matarin, Karen A. Mather, Manuel Mattheisen, Morten Mattingsdal, Andreas Meyer-Lindenberg, Colm McDonald, Andrew M. McIntosh, Francis J. McMahon, Katie L. McMahon, Eva Meisenzahl, Ingrid Melle, Yuri Milaneschi, Sebastian Mohnke, Grant W. Montgomery, Derek W. Morris, Eric K. Moses, Bryon A. Mueller, Susana Muñoz Maniega, Thomas W. Mühleisen, Bertram Müller-Myhsok, Benson Mwangi, Matthias Nauck, Kwangsik Nho, Thomas E. Nichols, Lars Göran Nilsson, Allison C. Nugent, Lars Nyberg, Rene L. Olvera, Jaap Oosterlaan, Roel A. Ophoff, Massimo Pandolfo, Melina Papalampropoulou-Tsiridou, Martina Papmeyer, Tomas Paus, Zdenka Pausova, Godfrey D. Pearlson, Brenda W. Penninx, Charles P. Peterson, Andrea Pfennig, Mary Phillips, G. Bruce Pike, Jean Baptiste Poline, Steven G. Potkin, Benno Pütz, Adaikalavan Ramasamy, Jerod Rasmussen, Marcella Rietschel, Mark Rijpkema, Shannon L. Risacher, Joshua L. Roffman, Roberto Roiz-Santiañez, Nina Romanczuk-Seiferth, Emma J. Rose, Natalie A. Royle, Dan Rujescu, Mina Ryten, Perminder S. Sachdev, Alireza Salami, Theodore D. Satterthwaite, Jonathan Savitz, Andrew J. Saykin, Cathy Scanlon, Lianne Schmaal, Hugo G. Schnack, Andrew J. Schork, S. Charles Schulz, Remmelt Schür, Larry Seidman, Li Shen, Jody M. Shoemaker, Andrew Simmons, Sanjay M. Sisodiya, Colin Smith, Jordan W. Smoller, Jair C. Soares, Scott R. Sponheim, Emma Sprooten, John M. Starr, Vidar M. Steen, Stephen Strakowski, Lachlan Strike, Jessika Sussmann, Philipp G. Sämann, Alexander Teumer, Arthur W. Toga, Diana Tordesillas-Gutierrez, Daniah Trabzuni, Sarah Trost, Jessica Turner, Martijn Van den Heuvel, Nic J. van der Wee, Kristel van Eijk, Theo G.M. van Erp, Neeltje E.M. van Haren, Dennis van 't Ent, Marie Jose van Tol, Maria C. Valdés Hernández, Dick J. Veltman, Amelia Versace, Henry Völzke, Robert Walker, Henrik Walter, Lei Wang, Joanna M. Wardlaw, Michael E. Weale, Michael W. Weiner, Wei Wen, Lars T. Westlye, Heather C. Whalley, Christopher D. Whelan, Tonya White, Anderson M. Winkler, Katharina Wittfeld, Girma Woldehawariat, Christiane Wolf, David Zilles, Marcel P. Zwiers, Anbupalam Thalamuthu, Peter R. Schofield, Nelson B. Freimer, Natalia S. Lawrence, Wayne Drevets

Research output: Contribution to journalArticlepeer-review

398 Scopus citations

Abstract

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.

Original languageEnglish (US)
Pages (from-to)153-182
Number of pages30
JournalBrain Imaging and Behavior
Volume8
Issue number2
DOIs
StatePublished - Jun 2014

Keywords

  • Consortium
  • GWAS
  • Genetics
  • MRI
  • Meta-analysis
  • Multi-site

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

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