The enhancement of lymphocyte localization in skin sites of sheep by tumor necrosis factor alpha

A. N. Kalaaji; K. McCullough; J. B. Hay

doi:10.1016/0165-2478(89)90127-2

The enhancement of lymphocyte localization in skin sites of sheep by tumor necrosis factor alpha

A. N. Kalaaji, K. McCullough, J. B. Hay

Dermatology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Using radiolabelled lymphocytes, we have demonstrated that recombinant bovine TNFα is potent in its ability to recruit lymphocytes from the blood into TNFα injected skin sites. Furthermore, TNFα mediates this observed increase in lymphocyte accumulation in a clear dose-response manner, and may play an important role in the mediation of DTH reactions in the skin.

Original language	English (US)
Pages (from-to)	143-147
Number of pages	5
Journal	Immunology Letters
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/0165-2478(89)90127-2
State	Published - Dec 1989

Keywords

Cytokine
Lymphocyte migration

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0165-2478(89)90127-2

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title = "The enhancement of lymphocyte localization in skin sites of sheep by tumor necrosis factor alpha",

abstract = "Using radiolabelled lymphocytes, we have demonstrated that recombinant bovine TNFα is potent in its ability to recruit lymphocytes from the blood into TNFα injected skin sites. Furthermore, TNFα mediates this observed increase in lymphocyte accumulation in a clear dose-response manner, and may play an important role in the mediation of DTH reactions in the skin.",

keywords = "Cytokine, Lymphocyte migration",

author = "Kalaaji, {A. N.} and K. McCullough and Hay, {J. B.}",

note = "Funding Information: This work was supported by the Medical Research Council of Canada and the Multiple Sclerosis Society of Canada.",

year = "1989",

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doi = "10.1016/0165-2478(89)90127-2",

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AU - Kalaaji, A. N.

AU - McCullough, K.

AU - Hay, J. B.

N1 - Funding Information: This work was supported by the Medical Research Council of Canada and the Multiple Sclerosis Society of Canada.

PY - 1989/12

Y1 - 1989/12

N2 - Using radiolabelled lymphocytes, we have demonstrated that recombinant bovine TNFα is potent in its ability to recruit lymphocytes from the blood into TNFα injected skin sites. Furthermore, TNFα mediates this observed increase in lymphocyte accumulation in a clear dose-response manner, and may play an important role in the mediation of DTH reactions in the skin.

AB - Using radiolabelled lymphocytes, we have demonstrated that recombinant bovine TNFα is potent in its ability to recruit lymphocytes from the blood into TNFα injected skin sites. Furthermore, TNFα mediates this observed increase in lymphocyte accumulation in a clear dose-response manner, and may play an important role in the mediation of DTH reactions in the skin.

KW - Cytokine

KW - Lymphocyte migration

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U2 - 10.1016/0165-2478(89)90127-2

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JO - Immunology Letters

JF - Immunology Letters

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ER -

The enhancement of lymphocyte localization in skin sites of sheep by tumor necrosis factor alpha

Abstract

Keywords

ASJC Scopus subject areas

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