The enhancement of lymphocyte localization in skin sites of sheep by tumor necrosis factor alpha

A. N. Kalaaji, K. McCullough, J. B. Hay

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Using radiolabelled lymphocytes, we have demonstrated that recombinant bovine TNFα is potent in its ability to recruit lymphocytes from the blood into TNFα injected skin sites. Furthermore, TNFα mediates this observed increase in lymphocyte accumulation in a clear dose-response manner, and may play an important role in the mediation of DTH reactions in the skin.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalImmunology Letters
Volume23
Issue number2
DOIs
StatePublished - Dec 1989

Keywords

  • Cytokine
  • Lymphocyte migration

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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