The emerging role of qsox1 in cancer

Douglas F. Lake, Douglas Orrick Faigel

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Significance: Quiescin sulfhydryl oxidase 1 (QSOX1) is an enzyme that oxidizes thiols during protein folding, reducing molecular oxygen to hydrogen peroxide. Tumor cells may take advantage of oxidative environments at different stages of tumorigenesis, but QSOX1 may also serve additional functions in tumors. Recent Advances: Several groups have reported the over-expression of QSOX1 in breast, pancreas, and prostate cancers. A consensus is building that QSOX1 over-expression is important during tumor cell invasion, facilitating tumor cell migration at the tumor-stroma interface. As such, QSOX1 may be considered a prognostic indicator of metastatic potential or even indicate that cancer is present in a host. Critical Issues: However, some controversy exists between QSOX1 as a marker of poor or favorable outcome in breast cancer. More studies are required to reveal what advantage QSOX1 provides to breast and other types of cancer. More specifically, it is critical to learn which tumor types over-express QSOX1 and use its enzymatic activity to their advantage. Future Directions: As interest increases in understanding the mechanisms of tumorigenesis within the extracellular matrix and how tumor cells influence fibroblasts and other stromal cells, QSOX1 may be revealed as an important player in cancer detection and prognosis. Defining the mechanism(s) of QSOX1 activity in tumors and in in vivo models will provide important insights into how to target QSOX1 with anti-neoplastic agents. Antioxid. Redox Signal. 21, 485-496.

Original languageEnglish (US)
Pages (from-to)485-496
Number of pages12
JournalAntioxidants and Redox Signaling
Volume21
Issue number3
DOIs
StatePublished - Jul 20 2014

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Tumors
Neoplasms
Cells
Breast Neoplasms
Carcinogenesis
sulfhydryl oxidase
Protein folding
Molecular oxygen
Protein Folding
Fibroblasts
Stromal Cells
Pancreatic Neoplasms
Sulfhydryl Compounds
Hydrogen Peroxide
Oxidation-Reduction
Cell Movement
Extracellular Matrix
Prostatic Neoplasms
Oxygen
Enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry
  • Medicine(all)

Cite this

The emerging role of qsox1 in cancer. / Lake, Douglas F.; Faigel, Douglas Orrick.

In: Antioxidants and Redox Signaling, Vol. 21, No. 3, 20.07.2014, p. 485-496.

Research output: Contribution to journalArticle

Lake, Douglas F. ; Faigel, Douglas Orrick. / The emerging role of qsox1 in cancer. In: Antioxidants and Redox Signaling. 2014 ; Vol. 21, No. 3. pp. 485-496.
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