TY - JOUR
T1 - The emerging role of oncolytic virus therapy against cancer
AU - Russell, Luke
AU - Peng, Kah Whye
N1 - Publisher Copyright:
© Chinese Clinical Oncology.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - This review discusses current clinical advancements in oncolytic viral therapy, with a focus on the viral platforms approved for clinical use and highlights the benefits each platform provides. Three oncolytic viruses (OVs), an echovirus, an adenovirus, and a herpes simplex-1 virus, have passed governmental regulatory approval in Latvia, China, and the USA and EU. Numerous other recombinant viruses from diverse families are in clinical testing in cancer patients and we highlight the design features of selected examples, including adenovirus, herpes simplex virus, measles virus, retrovirus, reovirus, vaccinia virus, vesicular stomatitis virus. Lastly, we provide thoughts on the path forward for this rapidly expanding field especially in combination with immune modulating drugs.
AB - This review discusses current clinical advancements in oncolytic viral therapy, with a focus on the viral platforms approved for clinical use and highlights the benefits each platform provides. Three oncolytic viruses (OVs), an echovirus, an adenovirus, and a herpes simplex-1 virus, have passed governmental regulatory approval in Latvia, China, and the USA and EU. Numerous other recombinant viruses from diverse families are in clinical testing in cancer patients and we highlight the design features of selected examples, including adenovirus, herpes simplex virus, measles virus, retrovirus, reovirus, vaccinia virus, vesicular stomatitis virus. Lastly, we provide thoughts on the path forward for this rapidly expanding field especially in combination with immune modulating drugs.
KW - Antitumor immunity
KW - Cancer
KW - Oncolytic
KW - Virus
UR - http://www.scopus.com/inward/record.url?scp=85047007611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047007611&partnerID=8YFLogxK
U2 - 10.21037/cco.2018.04.04
DO - 10.21037/cco.2018.04.04
M3 - Review article
C2 - 29764161
AN - SCOPUS:85047007611
SN - 2304-3865
VL - 7
JO - Chinese clinical oncology
JF - Chinese clinical oncology
IS - 2
M1 - 16
ER -