The emerging role of mitochondrial targeting in kidney disease

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Scopus citations

Abstract

Renal disease affects millions of people worldwide, imposing an enormous financial burden for health-care systems. Recent evidence suggests that mitochondria play an important role in the pathogenesis of different forms of renal disease, including genetic defects, acute kidney injury, chronic kidney disease, aging, renal tumors, and transplant nephropathy. Renal mitochondrial abnormalities and dysfunction affect several cellular pathways, leading to increased oxidative stress, apoptosis, microvascular loss, and fibrosis, all of which compromise renal function. Over recent years, compounds that specifically target mitochondria have emerged as promising therapeutic options for patients with renal disease. Although the most compelling evidence is based on preclinical studies, several compounds are currently being tested in clinical trials. This chapter provides an overview of the involvement of mitochondrial dysfunction in renal disease and summarizes the current knowledge on mitochondria-targeted strategies to attenuate renal disease.

Original languageEnglish (US)
Title of host publicationHandbook of Experimental Pharmacology
PublisherSpringer New York LLC
Pages229-250
Number of pages22
Volume240
DOIs
StatePublished - 2017

Publication series

NameHandbook of Experimental Pharmacology
Volume240
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • ATP
  • Cardiolipin
  • Kidney
  • Mitochondria

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Eirin, A., Lerman, A., & Lerman, L. O. (2017). The emerging role of mitochondrial targeting in kidney disease. In Handbook of Experimental Pharmacology (Vol. 240, pp. 229-250). (Handbook of Experimental Pharmacology; Vol. 240). Springer New York LLC. https://doi.org/10.1007/164_2016_6