The elusive Minnie G. Revisiting Cushing's case XLV, and his early attempts at improving quality of life

Courtney Pendleton, Hadie Adams, Edward R. Laws, Alfredo Quinones-Hinojosa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Although researchers have discovered that Minnie G. had nearly 50 years of progression-free survival, the absence of her original surgical records have precluded anything more than speculation as to the etiology of her symptoms or the details of her admission. Following IRB approval, and through the courtesy of the Alan Mason Chesney Archives, the microfilm surgical records from the Johns Hopkins Hospital, 1896-1912 were reviewed. Using the surgical number provided in Cushing's publications, the record for Minnie G. was recovered for further review. Cushing's diagnosis relied largely on history and physical findings. Minnie G. presented with stigmata associated with classic Cushings Syndrome: abdominal stria, supraclavicular fat pads, and a rounded face. However, she also presented with unusual physical findings: exophthalmos, and irregular pigmentation of the extremities, face, and eyelids. A note in the chart indicates Minnie G. spoke very little English, implying the history-taking was fraught with opportunities for error. Although there remains no definitive etiology for Minnie G.'s symptoms, this report contributes additional information about her diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)361-366
Number of pages6
JournalPituitary
Volume13
Issue number4
DOIs
StatePublished - Dec 2010
Externally publishedYes

Fingerprint

History
Quality of Life
Christianity
Exophthalmos
Cushing Syndrome
Research Ethics Committees
Pigmentation
Eyelids
Disease-Free Survival
Publications
Adipose Tissue
Extremities
Research Personnel

Keywords

  • Cushing's syndrome
  • Harvey Cushing
  • Minnie G.

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The elusive Minnie G. Revisiting Cushing's case XLV, and his early attempts at improving quality of life. / Pendleton, Courtney; Adams, Hadie; Laws, Edward R.; Quinones-Hinojosa, Alfredo.

In: Pituitary, Vol. 13, No. 4, 12.2010, p. 361-366.

Research output: Contribution to journalArticle

Pendleton, Courtney ; Adams, Hadie ; Laws, Edward R. ; Quinones-Hinojosa, Alfredo. / The elusive Minnie G. Revisiting Cushing's case XLV, and his early attempts at improving quality of life. In: Pituitary. 2010 ; Vol. 13, No. 4. pp. 361-366.
@article{d4af87115c0f440486d40b2cc9923358,
title = "The elusive Minnie G.: Revisiting Cushing's case XLV, and his early attempts at improving quality of life",
abstract = "Although researchers have discovered that Minnie G. had nearly 50 years of progression-free survival, the absence of her original surgical records have precluded anything more than speculation as to the etiology of her symptoms or the details of her admission. Following IRB approval, and through the courtesy of the Alan Mason Chesney Archives, the microfilm surgical records from the Johns Hopkins Hospital, 1896-1912 were reviewed. Using the surgical number provided in Cushing's publications, the record for Minnie G. was recovered for further review. Cushing's diagnosis relied largely on history and physical findings. Minnie G. presented with stigmata associated with classic Cushings Syndrome: abdominal stria, supraclavicular fat pads, and a rounded face. However, she also presented with unusual physical findings: exophthalmos, and irregular pigmentation of the extremities, face, and eyelids. A note in the chart indicates Minnie G. spoke very little English, implying the history-taking was fraught with opportunities for error. Although there remains no definitive etiology for Minnie G.'s symptoms, this report contributes additional information about her diagnosis and treatment.",
keywords = "Cushing's syndrome, Harvey Cushing, Minnie G.",
author = "Courtney Pendleton and Hadie Adams and Laws, {Edward R.} and Alfredo Quinones-Hinojosa",
year = "2010",
month = "12",
doi = "10.1007/s11102-010-0248-1",
language = "English (US)",
volume = "13",
pages = "361--366",
journal = "Pituitary",
issn = "1386-341X",
publisher = "Kluwer Academic Publishers",
number = "4",

}

TY - JOUR

T1 - The elusive Minnie G.

T2 - Revisiting Cushing's case XLV, and his early attempts at improving quality of life

AU - Pendleton, Courtney

AU - Adams, Hadie

AU - Laws, Edward R.

AU - Quinones-Hinojosa, Alfredo

PY - 2010/12

Y1 - 2010/12

N2 - Although researchers have discovered that Minnie G. had nearly 50 years of progression-free survival, the absence of her original surgical records have precluded anything more than speculation as to the etiology of her symptoms or the details of her admission. Following IRB approval, and through the courtesy of the Alan Mason Chesney Archives, the microfilm surgical records from the Johns Hopkins Hospital, 1896-1912 were reviewed. Using the surgical number provided in Cushing's publications, the record for Minnie G. was recovered for further review. Cushing's diagnosis relied largely on history and physical findings. Minnie G. presented with stigmata associated with classic Cushings Syndrome: abdominal stria, supraclavicular fat pads, and a rounded face. However, she also presented with unusual physical findings: exophthalmos, and irregular pigmentation of the extremities, face, and eyelids. A note in the chart indicates Minnie G. spoke very little English, implying the history-taking was fraught with opportunities for error. Although there remains no definitive etiology for Minnie G.'s symptoms, this report contributes additional information about her diagnosis and treatment.

AB - Although researchers have discovered that Minnie G. had nearly 50 years of progression-free survival, the absence of her original surgical records have precluded anything more than speculation as to the etiology of her symptoms or the details of her admission. Following IRB approval, and through the courtesy of the Alan Mason Chesney Archives, the microfilm surgical records from the Johns Hopkins Hospital, 1896-1912 were reviewed. Using the surgical number provided in Cushing's publications, the record for Minnie G. was recovered for further review. Cushing's diagnosis relied largely on history and physical findings. Minnie G. presented with stigmata associated with classic Cushings Syndrome: abdominal stria, supraclavicular fat pads, and a rounded face. However, she also presented with unusual physical findings: exophthalmos, and irregular pigmentation of the extremities, face, and eyelids. A note in the chart indicates Minnie G. spoke very little English, implying the history-taking was fraught with opportunities for error. Although there remains no definitive etiology for Minnie G.'s symptoms, this report contributes additional information about her diagnosis and treatment.

KW - Cushing's syndrome

KW - Harvey Cushing

KW - Minnie G.

UR - http://www.scopus.com/inward/record.url?scp=78049293658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049293658&partnerID=8YFLogxK

U2 - 10.1007/s11102-010-0248-1

DO - 10.1007/s11102-010-0248-1

M3 - Article

C2 - 20711851

AN - SCOPUS:78049293658

VL - 13

SP - 361

EP - 366

JO - Pituitary

JF - Pituitary

SN - 1386-341X

IS - 4

ER -