The efficacy, safety, and predictors of outcomes of transarterial radioembolization for hepatocellular carcinoma: a retrospective study

Mohamed A. Abdallah, Nicha Wongjarupong, Mohamed A. Hassan, Wesam Taha, Abubaker Abdalla, Sally Bampoh, Kristeen Onyirioha, Morgan Nelson, Lyn A. Glubranson, Gregory A. Wiseman, Chad J. Fleming, James C. Andrews, Amit Mahipal, Lewis R. Roberts

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objectives: Yttrium-90 transarterial radioembolization (TARE) is a safe, effective modality of locoregional therapy for intermediate and advanced-stage hepatocellular carcinoma (HCC). We aim to identify novel predictors of important outcomes of TARE therapy. Methods: A single-center retrospective study of 166 patients treated with TARE for HCC at Mayo Clinic Rochester between 2005-2015 and followed until December 2017. Multivariate logistic and stepwise regression analysis models were used to identify variables associated with overall survival (OS) and progression-free survival (PFS). Results: The median OS and the median PFS were12.9  (95% CI: 11.0–17.3), and 8 months (95% CI: 6–11), respectively. Macrovascular invasion (HR: 1.9 [1.3–2.8]), Child-Pugh score (CPS) B or C vs. A (HR: 1.8 [1.2–2.7]), Eastern Cooperative Oncology Group Performance status (ECOG-PS) 2 or 1 vs. 0 (HR: 1.6 [1.1–2.4]) and activity (A) of administered radiation dose (HR: 1.005[1.00–1.010), independently correlated with poorer OS. Infiltrative HCC (HR: 2.4 [1.3–4.5), macrovascular invasion (HR: 1.6 [1.1–2.7]), and high activity of administered radiation dose (HR: 1.005 [1.00–1.010) were associated with worse PFS. Conclusion: In HCC patients treated with TARE; macrovascular invasion, the activity of radiation dose, CPS, ECOG-PS, and infiltrative HCC predict OS and PFS.

Original languageEnglish (US)
Pages (from-to)619-629
Number of pages11
JournalExpert Review of Gastroenterology and Hepatology
Volume14
Issue number7
DOIs
StatePublished - Jul 2 2020

Keywords

  • Neutrophil to lymphocyte ratio
  • child-pugh score
  • hepatocellular carcinoma
  • macrovascular invasion
  • monocyte to lymphocyte ratio
  • platelet to lymphocyte ratio
  • transarterial radioembolization

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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