The efficacy of gadobenate dimeglumine (Gd-BOPTA) at 3 Tesla in brain magnetic resonance imaging: Comparison to 1.5 Tesla and a standard gadolinium chelate using a rat brain tumor model

Val M. Runge, Jonmenjoy Biswas, Bernd J. Wintersperger, Shannon S. Baumann, Carney B. Jackson, Christoph U. Herborn, Tushar Patel

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

OBJECTIVES: The objectives of this study were to analyze the differences in contrast enhancement using gadobenate dimeglumine (Gd-BOPTA or MultiHance) at 3 T versus 1.5 T and to compare Gd-BOPTA with a standard gadolinium chelate, gadopentetate dimeglumine (Gd-DTPA or Magnevist), at 3 T in a rat glioma model. MATERIALS AND METHODS: Twelve rats with surgically implanted gliomas were randomized to either comparing Gd-BOPTA at 1.5 T versus 3 T (n = 7) or comparing Gd-BOPTA and Gd-DTPA at 3 T (n = 5). Matched T1-weighted spin-echo techniques were used for both comparisons and the order of examinations was randomized. Signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and lesion enhancement (LE) were evaluated using a region-of-interest analysis. A veterinary histopathologist evaluated all brain specimens. RESULTS: In the evaluation of Gd-BOPTA at 3 T and 1.5 T, there were significant increases in SNR, LE, and CNR at 3 T. Average increases in brain and tumor SNR were 93% (P < 0.0001) and 92% (P < 0.0001), respectively. CNR increased by 121% (P < 0.0001). Comparison of Gd-BOPTA and Gd-DTPA at 3 T demonstrated significantly higher CNR and LE with Gd-BOPTA. CNR increased by 35% (P = 0.002). LE increased by 44% (P = 0.03). CONCLUSIONS: Gd-BOPTA provides significantly higher CNR at 3 T compared with 1.5 T and also demonstrates significantly higher CNR when compared with a standard Gd-chelate at 3 T. As a result of transient protein binding, Gd-BOPTA may be superior to standard gadolinium chelates in neurologic imaging at 3 T.

Original languageEnglish (US)
Pages (from-to)244-248
Number of pages5
JournalInvestigative radiology
Volume41
Issue number3
DOIs
StatePublished - Mar 1 2006

Keywords

  • Brain neoplasms
  • Contrast enhancement
  • Gadobenate dimeglumine
  • Gadolinium chelates
  • Magnetic resonance

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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