The efficacy of continuous positive airway pressure therapy in reducing cardiovascular events in obstructive sleep apnea: A systematic review

Christine Parsons, Sorcha Allen, James Parish, Farouk Mookadam, Martina Mookadam

Research output: Contribution to journalReview article

1 Scopus citations


Prospective studies show an association between obstructive sleep apnea and cardiovascular disease. Continuous positive airway pressure (CPAP) is the treatment of choice and effectively reduces subjective sleepiness and apneic and hypopneic events. However, randomized trials have not shown a reduction in cardiovascular outcomes with CPAP therapy. We review the past 10 years of randomized trial evidence regarding the therapeutic efficacy of CPAP on cardiovascular outcomes and mortality in adults with obstructive sleep apnea. The majority of studies found no significant improvement in cardiovascular outcomes with CPAP, although many noted nonsignificant benefits. Adjusted analysis in several trials showed significant cardiovascular benefit in those patients with higher CPAP compliance. Existing trials may lack sufficient follow-up and CPAP compliance, among other limitations.

Original languageEnglish (US)
Pages (from-to)397-412
Number of pages16
JournalFuture Cardiology
Issue number4
StatePublished - Jul 1 2017



  • cardiovascular events
  • continuous positive airway pressure
  • mortality
  • obstructive sleep apnea

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine

Cite this