The efficacy of continuous positive airway pressure therapy in reducing cardiovascular events in obstructive sleep apnea: A systematic review

Christine Parsons, Sorcha Allen, James Parish, Farouk Mookadam, Martina Mookadam

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Prospective studies show an association between obstructive sleep apnea and cardiovascular disease. Continuous positive airway pressure (CPAP) is the treatment of choice and effectively reduces subjective sleepiness and apneic and hypopneic events. However, randomized trials have not shown a reduction in cardiovascular outcomes with CPAP therapy. We review the past 10 years of randomized trial evidence regarding the therapeutic efficacy of CPAP on cardiovascular outcomes and mortality in adults with obstructive sleep apnea. The majority of studies found no significant improvement in cardiovascular outcomes with CPAP, although many noted nonsignificant benefits. Adjusted analysis in several trials showed significant cardiovascular benefit in those patients with higher CPAP compliance. Existing trials may lack sufficient follow-up and CPAP compliance, among other limitations.

Original languageEnglish (US)
Pages (from-to)397-412
Number of pages16
JournalFuture Cardiology
Volume13
Issue number4
DOIs
StatePublished - Jul 1 2017

Fingerprint

Continuous Positive Airway Pressure
Obstructive Sleep Apnea
Therapeutics
Cardiovascular Diseases
Prospective Studies
Mortality

Keywords

  • cardiovascular events
  • continuous positive airway pressure
  • mortality
  • obstructive sleep apnea

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

The efficacy of continuous positive airway pressure therapy in reducing cardiovascular events in obstructive sleep apnea : A systematic review. / Parsons, Christine; Allen, Sorcha; Parish, James; Mookadam, Farouk; Mookadam, Martina.

In: Future Cardiology, Vol. 13, No. 4, 01.07.2017, p. 397-412.

Research output: Contribution to journalReview article

Parsons, Christine ; Allen, Sorcha ; Parish, James ; Mookadam, Farouk ; Mookadam, Martina. / The efficacy of continuous positive airway pressure therapy in reducing cardiovascular events in obstructive sleep apnea : A systematic review. In: Future Cardiology. 2017 ; Vol. 13, No. 4. pp. 397-412.
@article{17ee5a99aca34fef9eddb3ae34d2df16,
title = "The efficacy of continuous positive airway pressure therapy in reducing cardiovascular events in obstructive sleep apnea: A systematic review",
abstract = "Prospective studies show an association between obstructive sleep apnea and cardiovascular disease. Continuous positive airway pressure (CPAP) is the treatment of choice and effectively reduces subjective sleepiness and apneic and hypopneic events. However, randomized trials have not shown a reduction in cardiovascular outcomes with CPAP therapy. We review the past 10 years of randomized trial evidence regarding the therapeutic efficacy of CPAP on cardiovascular outcomes and mortality in adults with obstructive sleep apnea. The majority of studies found no significant improvement in cardiovascular outcomes with CPAP, although many noted nonsignificant benefits. Adjusted analysis in several trials showed significant cardiovascular benefit in those patients with higher CPAP compliance. Existing trials may lack sufficient follow-up and CPAP compliance, among other limitations.",
keywords = "cardiovascular events, continuous positive airway pressure, mortality, obstructive sleep apnea",
author = "Christine Parsons and Sorcha Allen and James Parish and Farouk Mookadam and Martina Mookadam",
year = "2017",
month = "7",
day = "1",
doi = "10.2217/fca-2017-0004",
language = "English (US)",
volume = "13",
pages = "397--412",
journal = "Future Cardiology",
issn = "1479-6678",
publisher = "Future Medicine Ltd.",
number = "4",

}

TY - JOUR

T1 - The efficacy of continuous positive airway pressure therapy in reducing cardiovascular events in obstructive sleep apnea

T2 - A systematic review

AU - Parsons, Christine

AU - Allen, Sorcha

AU - Parish, James

AU - Mookadam, Farouk

AU - Mookadam, Martina

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Prospective studies show an association between obstructive sleep apnea and cardiovascular disease. Continuous positive airway pressure (CPAP) is the treatment of choice and effectively reduces subjective sleepiness and apneic and hypopneic events. However, randomized trials have not shown a reduction in cardiovascular outcomes with CPAP therapy. We review the past 10 years of randomized trial evidence regarding the therapeutic efficacy of CPAP on cardiovascular outcomes and mortality in adults with obstructive sleep apnea. The majority of studies found no significant improvement in cardiovascular outcomes with CPAP, although many noted nonsignificant benefits. Adjusted analysis in several trials showed significant cardiovascular benefit in those patients with higher CPAP compliance. Existing trials may lack sufficient follow-up and CPAP compliance, among other limitations.

AB - Prospective studies show an association between obstructive sleep apnea and cardiovascular disease. Continuous positive airway pressure (CPAP) is the treatment of choice and effectively reduces subjective sleepiness and apneic and hypopneic events. However, randomized trials have not shown a reduction in cardiovascular outcomes with CPAP therapy. We review the past 10 years of randomized trial evidence regarding the therapeutic efficacy of CPAP on cardiovascular outcomes and mortality in adults with obstructive sleep apnea. The majority of studies found no significant improvement in cardiovascular outcomes with CPAP, although many noted nonsignificant benefits. Adjusted analysis in several trials showed significant cardiovascular benefit in those patients with higher CPAP compliance. Existing trials may lack sufficient follow-up and CPAP compliance, among other limitations.

KW - cardiovascular events

KW - continuous positive airway pressure

KW - mortality

KW - obstructive sleep apnea

UR - http://www.scopus.com/inward/record.url?scp=85022230747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85022230747&partnerID=8YFLogxK

U2 - 10.2217/fca-2017-0004

DO - 10.2217/fca-2017-0004

M3 - Review article

C2 - 28631492

AN - SCOPUS:85022230747

VL - 13

SP - 397

EP - 412

JO - Future Cardiology

JF - Future Cardiology

SN - 1479-6678

IS - 4

ER -