The effects of monoamine oxidase B inhibition on dopamine metabolism in rats with nigro-striatal lesions

E. Scarr, Dean Marko Wingerchuk, A. V. Juorio, I. A. Paterson

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The purpose of this study was to examine whether monoamine oxidase type B (MAO-B) has a role in striatal dopamine metabolism in animals with a unilateral lesion of the medial forebrain bundle, and whether 2-phenylethylamine (PE) could have a role in amplification of dopamine (DA) responses in DA depleted striatum. Inhibition of MAO-B did not alter DA metabolism in lesioned striata. PE accumulation decreased with loss of DA as long as there was no DA dysfunction. In lesioned striata with dysfunction of DA transmission at the synaptic level, PE accumulation increased, suggesting a compensatory increase in PE synthesis. This increase in PE levels does not appear to be mediated by an increase in the total striatal aromatic l-amino acid decarboxylase (AADC) activity. We conclude that inhibition of MAO-B has no effect on DA metabolism in the hemi-parkinsonian rat striatum and that PE could be involved in the antiparkinsonian action of MAO-B inhibitors.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalNeurochemical Research
Volume19
Issue number2
DOIs
StatePublished - Feb 1994
Externally publishedYes

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Enzyme inhibition
Corpus Striatum
Monoamine Oxidase
Metabolism
Rats
Dopamine
Aromatic-L-Amino-Acid Decarboxylases
Medial Forebrain Bundle
Antiparkinson Agents
Monoamine Oxidase Inhibitors
Carboxy-Lyases
Carboxylic acids
Synaptic Transmission
Amplification
phenethylamine
Animals
Amino Acids

Keywords

  • 2-Phenylethylamine
  • Aromatic l-amino acid decarboxylase
  • Dopamine
  • Inhibition
  • Metabolism
  • Monoamine oxidase B

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

The effects of monoamine oxidase B inhibition on dopamine metabolism in rats with nigro-striatal lesions. / Scarr, E.; Wingerchuk, Dean Marko; Juorio, A. V.; Paterson, I. A.

In: Neurochemical Research, Vol. 19, No. 2, 02.1994, p. 153-159.

Research output: Contribution to journalArticle

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