The effects of metabolic conditions on prostate cancer incidence over 15 years of follow-up: Results from the Olmsted County Study

Lauren P. Wallner, Hal Morgenstern, Michaela E. McGree, Debra J. Jacobson, Jennifer L. St Sauver, Steven J. Jacobsen, Aruna V. Sarma

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

OBJECTIVE: • To determine if combinations of obesity hypertension and diabetes influence the development of prostate cancer over 15 years of follow-up. PATIENTS AND METHODS: • In 1990, a randomly selected cohort of Caucasian men from Olmsted County, MN, USA, aged 40-79 years, was recruited; 2445 completed a questionnaire that included physician-diagnosed diabetes and hypertension. • Anthropometric measures were collected during clinical examination. Biopsy-confirmed prostate cancer was identified from medical records. • Proportional hazards regression was used to estimate the effects of these metabolic conditions, both individually and in combination, on the incidence rate of prostate cancer. RESULTS: • Men with hypertension alone or in combination with diabetes were more likely to develop prostate cancer than were men without any of the metabolic conditions. • The metabolic syndrome - the presence of all three conditions compared with men with no metabolic components - was only minimally and inversely associated with prostate cancer [hazard ratio (HR): 0.81; 95% confidence interval (CI): 0.20, 3.3] and no monotonic association between the number of metabolic components and prostate cancer was observed. CONCLUSIONS: • Our results suggest that it may not be sufficient to treat metabolic conditions as one variable when investigating the aetiology of prostate cancer in Caucasian men. • Further research should focus on the separate and combined effects of these metabolic conditions in large samples.

Original languageEnglish (US)
Pages (from-to)929-935
Number of pages7
JournalBJU international
Volume107
Issue number6
DOIs
StatePublished - Mar 2011

Keywords

  • Diabetes
  • Hypertension
  • MeSH: Prostate cancer
  • Metabolic syndrome
  • Obesity

ASJC Scopus subject areas

  • Urology

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