Abstract
OBJECTIVE: • To determine if combinations of obesity hypertension and diabetes influence the development of prostate cancer over 15 years of follow-up. PATIENTS AND METHODS: • In 1990, a randomly selected cohort of Caucasian men from Olmsted County, MN, USA, aged 40-79 years, was recruited; 2445 completed a questionnaire that included physician-diagnosed diabetes and hypertension. • Anthropometric measures were collected during clinical examination. Biopsy-confirmed prostate cancer was identified from medical records. • Proportional hazards regression was used to estimate the effects of these metabolic conditions, both individually and in combination, on the incidence rate of prostate cancer. RESULTS: • Men with hypertension alone or in combination with diabetes were more likely to develop prostate cancer than were men without any of the metabolic conditions. • The metabolic syndrome - the presence of all three conditions compared with men with no metabolic components - was only minimally and inversely associated with prostate cancer [hazard ratio (HR): 0.81; 95% confidence interval (CI): 0.20, 3.3] and no monotonic association between the number of metabolic components and prostate cancer was observed. CONCLUSIONS: • Our results suggest that it may not be sufficient to treat metabolic conditions as one variable when investigating the aetiology of prostate cancer in Caucasian men. • Further research should focus on the separate and combined effects of these metabolic conditions in large samples.
Original language | English (US) |
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Pages (from-to) | 929-935 |
Number of pages | 7 |
Journal | BJU international |
Volume | 107 |
Issue number | 6 |
DOIs | |
State | Published - Mar 2011 |
Keywords
- Diabetes
- Hypertension
- MeSH: Prostate cancer
- Metabolic syndrome
- Obesity
ASJC Scopus subject areas
- Urology