The effects of intraocular silicone oil placement prior to iodine 125 brachytherapy for uveal melanoma: A clinical case series

Y. Ahuja, K. G. Kapoor, R. M. Thomson, K. M. Furutani, R. W. Shultz, S. L. Stafford, S. Dev, N. E. Abu-Yaghi, D. Reynolds, Jose S Pulido

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose To investigate the role of silicone oil as an adjunct to iodine 125 (125 I) brachytherapy in attenuating radiation dose and reducing radiation retinopathy.MethodsA 16-mm COMS plaque loaded with 125 I seeds was simulated in vitro on an eye model containing silicone oil as a vitreous substitute using BrachyDose. The radiation dose ratio of silicone oil vs water to ocular structures was calculated at angles subtended from the centre of the eye. Silicone oil was then used in three choroidal melanoma patients who underwent 23-gauge vitrectomy, silicone oil placement, and 125 I brachytherapy. ResultsSilicone oil reduced the ocular radiation dose in vitro to 65%. Radiation dose ratios on the retina increased from 0.45 to 0.99 when moving from points diametrically opposed to the plaques central axis. In 10-24 months follow-up, no patients have developed radiation retinopathy. Each patient required silicone oil removal and experienced cataract progression, and one also developed a retinal detachment.ConclusionsThis study confirms that silicone oil attenuates radiation dose in vitro, and may protect against radiation retinopathy clinically in patients, however it requires extensive surgical interventions. Further studies in only very selected populations using silicone oil as an adjunct to 125 I brachytherapy will best elucidate its role in shielding radiation retinopathy.

Original languageEnglish (US)
Pages (from-to)1487-1489
Number of pages3
JournalEye (Basingstoke)
Volume26
Issue number11
DOIs
StatePublished - Nov 2012

Fingerprint

Silicone Oils
Brachytherapy
Iodine
Radiation
Uveal melanoma
Vitrectomy
Retinal Detachment
Cataract
Retina
Melanoma
Seeds
Oils

Keywords

  • brachytherapy
  • retina
  • silicone oil

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The effects of intraocular silicone oil placement prior to iodine 125 brachytherapy for uveal melanoma : A clinical case series. / Ahuja, Y.; Kapoor, K. G.; Thomson, R. M.; Furutani, K. M.; Shultz, R. W.; Stafford, S. L.; Dev, S.; Abu-Yaghi, N. E.; Reynolds, D.; Pulido, Jose S.

In: Eye (Basingstoke), Vol. 26, No. 11, 11.2012, p. 1487-1489.

Research output: Contribution to journalArticle

Ahuja, Y, Kapoor, KG, Thomson, RM, Furutani, KM, Shultz, RW, Stafford, SL, Dev, S, Abu-Yaghi, NE, Reynolds, D & Pulido, JS 2012, 'The effects of intraocular silicone oil placement prior to iodine 125 brachytherapy for uveal melanoma: A clinical case series', Eye (Basingstoke), vol. 26, no. 11, pp. 1487-1489. https://doi.org/10.1038/eye.2012.158
Ahuja, Y. ; Kapoor, K. G. ; Thomson, R. M. ; Furutani, K. M. ; Shultz, R. W. ; Stafford, S. L. ; Dev, S. ; Abu-Yaghi, N. E. ; Reynolds, D. ; Pulido, Jose S. / The effects of intraocular silicone oil placement prior to iodine 125 brachytherapy for uveal melanoma : A clinical case series. In: Eye (Basingstoke). 2012 ; Vol. 26, No. 11. pp. 1487-1489.
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