The effects of Hylan G-F 20 surface modification on gliding of extrasynovial canine tendon grafts in vitro

Michail N. Kolodzinskyi, Chunfeng D Zhao, Yu Long Sun, Kai Nan An, Andrew R. Thoreson, Peter C Amadio, Steven Lawrence Moran

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: Studies have shown that a lubricant exogenously applied on extrasynovial tendon surfaces can reduce the gliding resistance after flexor tendon repair; however, the reagents that have been tested are solely for experimental testing and are not available for clinical use. The purpose of this study was to investigate the effect of exogenously applied hylan G-F 20, a U.S. Food and Drug Administration-approved hyaluronic acid for the treatment of osteoarthritis, on extrasynovial tendon gliding resistance in an in vitro canine model. Methods: Twenty-four canine peroneus longus (PL) tendons and proximal pulleys of the ipsilateral paws were treated with 1 of 3 solutions: saline, carbodiimide derivatized hylan G-F 20, or unmodified hylan G-F 20. The gliding resistance of each tendon preparation was then measured over 1000 cycles in a saline bath. Results: After 1,000 cycles, the gliding resistance of the PL tendons treated with unmodified hylan G-F 20 decreased significantly compared with the saline-treated tendons. The gliding resistance of the PL tendons treated with modified hylan G-F 20 increased significantly compared with the saline group. Conclusions: The PL tendons treated with pure hylan G-F 20 showed a positive effect on the gliding resistance. Clinical relevance: The results of this in vitro canine study suggest that exogenously applied hylan G-F 20 improves gliding of the extrasynovial tendon graft. This material may be capable of reducing friction over flexor tendon repair sites and flexor tendon grafts.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalJournal of Hand Surgery
Volume38
Issue number2
DOIs
StatePublished - Feb 2013

Fingerprint

Tendons
Canidae
Transplants
In Vitro Techniques
hylan
Carbodiimides
Lubricants
Friction
Hyaluronic Acid
United States Food and Drug Administration
Baths
Sodium Chloride
Osteoarthritis

Keywords

  • Adhesions
  • hyaluronic acid
  • tendon injury
  • tendon repair

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

The effects of Hylan G-F 20 surface modification on gliding of extrasynovial canine tendon grafts in vitro. / Kolodzinskyi, Michail N.; Zhao, Chunfeng D; Sun, Yu Long; An, Kai Nan; Thoreson, Andrew R.; Amadio, Peter C; Moran, Steven Lawrence.

In: Journal of Hand Surgery, Vol. 38, No. 2, 02.2013, p. 231-236.

Research output: Contribution to journalArticle

@article{625e38860be7472e9d81a6198c45bf84,
title = "The effects of Hylan G-F 20 surface modification on gliding of extrasynovial canine tendon grafts in vitro",
abstract = "Purpose: Studies have shown that a lubricant exogenously applied on extrasynovial tendon surfaces can reduce the gliding resistance after flexor tendon repair; however, the reagents that have been tested are solely for experimental testing and are not available for clinical use. The purpose of this study was to investigate the effect of exogenously applied hylan G-F 20, a U.S. Food and Drug Administration-approved hyaluronic acid for the treatment of osteoarthritis, on extrasynovial tendon gliding resistance in an in vitro canine model. Methods: Twenty-four canine peroneus longus (PL) tendons and proximal pulleys of the ipsilateral paws were treated with 1 of 3 solutions: saline, carbodiimide derivatized hylan G-F 20, or unmodified hylan G-F 20. The gliding resistance of each tendon preparation was then measured over 1000 cycles in a saline bath. Results: After 1,000 cycles, the gliding resistance of the PL tendons treated with unmodified hylan G-F 20 decreased significantly compared with the saline-treated tendons. The gliding resistance of the PL tendons treated with modified hylan G-F 20 increased significantly compared with the saline group. Conclusions: The PL tendons treated with pure hylan G-F 20 showed a positive effect on the gliding resistance. Clinical relevance: The results of this in vitro canine study suggest that exogenously applied hylan G-F 20 improves gliding of the extrasynovial tendon graft. This material may be capable of reducing friction over flexor tendon repair sites and flexor tendon grafts.",
keywords = "Adhesions, hyaluronic acid, tendon injury, tendon repair",
author = "Kolodzinskyi, {Michail N.} and Zhao, {Chunfeng D} and Sun, {Yu Long} and An, {Kai Nan} and Thoreson, {Andrew R.} and Amadio, {Peter C} and Moran, {Steven Lawrence}",
year = "2013",
month = "2",
doi = "10.1016/j.jhsa.2012.11.012",
language = "English (US)",
volume = "38",
pages = "231--236",
journal = "Journal of Hand Surgery",
issn = "0266-7681",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - The effects of Hylan G-F 20 surface modification on gliding of extrasynovial canine tendon grafts in vitro

AU - Kolodzinskyi, Michail N.

AU - Zhao, Chunfeng D

AU - Sun, Yu Long

AU - An, Kai Nan

AU - Thoreson, Andrew R.

AU - Amadio, Peter C

AU - Moran, Steven Lawrence

PY - 2013/2

Y1 - 2013/2

N2 - Purpose: Studies have shown that a lubricant exogenously applied on extrasynovial tendon surfaces can reduce the gliding resistance after flexor tendon repair; however, the reagents that have been tested are solely for experimental testing and are not available for clinical use. The purpose of this study was to investigate the effect of exogenously applied hylan G-F 20, a U.S. Food and Drug Administration-approved hyaluronic acid for the treatment of osteoarthritis, on extrasynovial tendon gliding resistance in an in vitro canine model. Methods: Twenty-four canine peroneus longus (PL) tendons and proximal pulleys of the ipsilateral paws were treated with 1 of 3 solutions: saline, carbodiimide derivatized hylan G-F 20, or unmodified hylan G-F 20. The gliding resistance of each tendon preparation was then measured over 1000 cycles in a saline bath. Results: After 1,000 cycles, the gliding resistance of the PL tendons treated with unmodified hylan G-F 20 decreased significantly compared with the saline-treated tendons. The gliding resistance of the PL tendons treated with modified hylan G-F 20 increased significantly compared with the saline group. Conclusions: The PL tendons treated with pure hylan G-F 20 showed a positive effect on the gliding resistance. Clinical relevance: The results of this in vitro canine study suggest that exogenously applied hylan G-F 20 improves gliding of the extrasynovial tendon graft. This material may be capable of reducing friction over flexor tendon repair sites and flexor tendon grafts.

AB - Purpose: Studies have shown that a lubricant exogenously applied on extrasynovial tendon surfaces can reduce the gliding resistance after flexor tendon repair; however, the reagents that have been tested are solely for experimental testing and are not available for clinical use. The purpose of this study was to investigate the effect of exogenously applied hylan G-F 20, a U.S. Food and Drug Administration-approved hyaluronic acid for the treatment of osteoarthritis, on extrasynovial tendon gliding resistance in an in vitro canine model. Methods: Twenty-four canine peroneus longus (PL) tendons and proximal pulleys of the ipsilateral paws were treated with 1 of 3 solutions: saline, carbodiimide derivatized hylan G-F 20, or unmodified hylan G-F 20. The gliding resistance of each tendon preparation was then measured over 1000 cycles in a saline bath. Results: After 1,000 cycles, the gliding resistance of the PL tendons treated with unmodified hylan G-F 20 decreased significantly compared with the saline-treated tendons. The gliding resistance of the PL tendons treated with modified hylan G-F 20 increased significantly compared with the saline group. Conclusions: The PL tendons treated with pure hylan G-F 20 showed a positive effect on the gliding resistance. Clinical relevance: The results of this in vitro canine study suggest that exogenously applied hylan G-F 20 improves gliding of the extrasynovial tendon graft. This material may be capable of reducing friction over flexor tendon repair sites and flexor tendon grafts.

KW - Adhesions

KW - hyaluronic acid

KW - tendon injury

KW - tendon repair

UR - http://www.scopus.com/inward/record.url?scp=84872961262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872961262&partnerID=8YFLogxK

U2 - 10.1016/j.jhsa.2012.11.012

DO - 10.1016/j.jhsa.2012.11.012

M3 - Article

C2 - 23294647

AN - SCOPUS:84872961262

VL - 38

SP - 231

EP - 236

JO - Journal of Hand Surgery

JF - Journal of Hand Surgery

SN - 0266-7681

IS - 2

ER -