The Effects of Deep Brain Stimulation in Patients with Multiple System Atrophy

Negin Badihian, Lauren M. Jackson, Bryan T. Klassen, Anhar Hassan, Phillip A. Low, Wolfgang Singer, Elizabeth A. Coon

Research output: Contribution to journalLetterpeer-review


The course of patients with multiple system atrophy (MSA) who undergo deep brain stimulation (DBS) is unclear. In a retrospective review of 1,496 patients with MSA evaluated at our institutions from 1998-2021, 12 patients underwent DBS; 9 had a diagnosis of Parkinson's disease at the time of surgery. Nine patients reported initial improvement in at least one symptom and 7 experienced overall worsening following DBS. All patients had at least one red flag sign or symptom suggesting atypical parkinsonism prior to surgery. Considering overall poor outcomes of DBS in MSA, we recommend careful consideration of red flags in patient selection.

Original languageEnglish (US)
Pages (from-to)2595-2600
Number of pages6
JournalJournal of Parkinson's disease
Issue number8
StatePublished - 2022


  • ataxia
  • deep brain stimulation
  • multiple system atrophy
  • parkinsonism
  • Parkinson’s disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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