The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetes

Michael J. Tansey, Eva Tsalikian, Roy W. Beck, Nelly Mauras, Bruce A. Buckingham, Stuart A. Weinzimer, Kathleen F. Janz, Craig Kollman, Dongyuan Xing, Katrina J. Ruedy, Michael W. Steffes, Timothy M. Borland, Ravinder J. Singh, William V. Tamborlane

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118 Scopus citations

Abstract

OBJECTIVE - To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS - Fifty children and adolescents with type 1 diabetes (ages 10 to <18 years) were studied during exercise. The 75-min exercise session consisted of four 15-min periods of walking on a treadmill to a target heart rate of 140 bpm and three 5-min rest periods. Blood glucose and plasma glucagon, cortisol, growth hormone, and norepinephrine concentrations were measured before, during, and after exercise. RESULTS - In most subjects (83%), plasma glucose concentration dropped at least 25% from baseline, and 15 (30%) subjects became hypoglycemic (≤60 mg/dl) or were treated for low glucose either during or immediately following the exercise session. The incidence of hypoglycemia and/or treatment for low glucose varied significantly by baseline glucose, occurring in 86 vs. 13 vs. 6% of subjects with baseline values <120, 120-180, and >180 mg/dl, respectively (P < 0.001). Exercise-induced increases in growth hormone and norepinephrine concentrations were marginally higher in subjects whose glucose dropped ≤70 mg/dl. Treatment of hypoglycemia with 15 g of oral glucose resulted in only about a 20-mg/dl rise in glucose concentrations. CONCLUSIONS - In youth with type 1 diabetes, prolonged moderate aerobic exercise results in a consistent reduction in plasma glucose and the frequent occurrence of hypoglycemia when preexercise glucose concentrations are <120 mg/dl. Moreover, treatment with 15 g of oral glucose is often insufficient to reliably treat hypoglycemia during exercise in these youngsters.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalDiabetes care
Volume29
Issue number1
DOIs
StatePublished - 2006

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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    Tansey, M. J., Tsalikian, E., Beck, R. W., Mauras, N., Buckingham, B. A., Weinzimer, S. A., Janz, K. F., Kollman, C., Xing, D., Ruedy, K. J., Steffes, M. W., Borland, T. M., Singh, R. J., & Tamborlane, W. V. (2006). The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetes. Diabetes care, 29(1), 20-25. https://doi.org/10.2337/diacare.29.01.06.dc05-1192