The effects of acute beta-adrenergic blockade on aortic wave reflection in postmenopausal women

Darren P. Casey, Timothy B Curry, Nisha Charkoudian, Michael Joseph Joyner, Emma C. Hart

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background Acute beta-adrenergic blockade increases aortic-wave reflection in young women. However, it is not known whether this effect extends to postmenopausal women. We therefore examined the effect of systemic beta-adrenergic blockade on aortic wave reflection in 14 postmenopausal women with a mean age of 58±2 years. Methods Aortic pressure waveforms were synthesized noninvasively from high-fidelity radial pressure waveforms obtained through applanation tonometry before and during systemic beta-blockade with propranolol given in a bolus dose of 0.25mg/kg, followed by a continuous infusion at 0.004mg/kg/min. To further examine the effects of acute beta-blockade on aortic-wave reflection in postmenopausal women, we compared the changes in hemodynamics and indices of aortic-wave reflection with published data from a previous study with a protocol identical to that in the present study but which involved young women. Results Acute beta-blockade increased the aortic augmentation index (AIx) in postmenopausal women (32±2% vs. 35±2%, P < 0.01). However, AIx adjusted for a heart rate of 75 bpm (AIx75) was unchanged (25±2% vs. 24±2%, P > 0.05). The changes in AIx, AIx75, and the amplitude of reflected waves (augmented aortic pressure) during beta-blockade were all substantially smaller in postmenopausal women than in their younger counterparts (P < 0.05).ConclusionsAs compared with those in our previously published study involving young women, indices of aortic-wave reflection were significantly less affected by acute systemic beta-adrenergic blockade in the postmenopausal women in the present study. Taken together, our data suggest that the negative effects (i.e. increased aortic wave reflection) of nonselective beta-adrenergic blockade are less pronounced in postmenopausal than in young women.

Original languageEnglish (US)
Pages (from-to)503-510
Number of pages8
JournalAmerican Journal of Hypertension
Volume26
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Adrenergic Agents
Arterial Pressure
Manometry
Propranolol
Hemodynamics
Pressure

Keywords

  • aortic wave reflection
  • beta-adrenergic receptors
  • blood pressure
  • hypertension
  • menopause

ASJC Scopus subject areas

  • Internal Medicine

Cite this

The effects of acute beta-adrenergic blockade on aortic wave reflection in postmenopausal women. / Casey, Darren P.; Curry, Timothy B; Charkoudian, Nisha; Joyner, Michael Joseph; Hart, Emma C.

In: American Journal of Hypertension, Vol. 26, No. 4, 04.2013, p. 503-510.

Research output: Contribution to journalArticle

@article{a9de5aa69d4a4b328694c4edb4499185,
title = "The effects of acute beta-adrenergic blockade on aortic wave reflection in postmenopausal women",
abstract = "Background Acute beta-adrenergic blockade increases aortic-wave reflection in young women. However, it is not known whether this effect extends to postmenopausal women. We therefore examined the effect of systemic beta-adrenergic blockade on aortic wave reflection in 14 postmenopausal women with a mean age of 58±2 years. Methods Aortic pressure waveforms were synthesized noninvasively from high-fidelity radial pressure waveforms obtained through applanation tonometry before and during systemic beta-blockade with propranolol given in a bolus dose of 0.25mg/kg, followed by a continuous infusion at 0.004mg/kg/min. To further examine the effects of acute beta-blockade on aortic-wave reflection in postmenopausal women, we compared the changes in hemodynamics and indices of aortic-wave reflection with published data from a previous study with a protocol identical to that in the present study but which involved young women. Results Acute beta-blockade increased the aortic augmentation index (AIx) in postmenopausal women (32±2{\%} vs. 35±2{\%}, P < 0.01). However, AIx adjusted for a heart rate of 75 bpm (AIx75) was unchanged (25±2{\%} vs. 24±2{\%}, P > 0.05). The changes in AIx, AIx75, and the amplitude of reflected waves (augmented aortic pressure) during beta-blockade were all substantially smaller in postmenopausal women than in their younger counterparts (P < 0.05).ConclusionsAs compared with those in our previously published study involving young women, indices of aortic-wave reflection were significantly less affected by acute systemic beta-adrenergic blockade in the postmenopausal women in the present study. Taken together, our data suggest that the negative effects (i.e. increased aortic wave reflection) of nonselective beta-adrenergic blockade are less pronounced in postmenopausal than in young women.",
keywords = "aortic wave reflection, beta-adrenergic receptors, blood pressure, hypertension, menopause",
author = "Casey, {Darren P.} and Curry, {Timothy B} and Nisha Charkoudian and Joyner, {Michael Joseph} and Hart, {Emma C.}",
year = "2013",
month = "4",
doi = "10.1093/ajh/hps074",
language = "English (US)",
volume = "26",
pages = "503--510",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - The effects of acute beta-adrenergic blockade on aortic wave reflection in postmenopausal women

AU - Casey, Darren P.

AU - Curry, Timothy B

AU - Charkoudian, Nisha

AU - Joyner, Michael Joseph

AU - Hart, Emma C.

PY - 2013/4

Y1 - 2013/4

N2 - Background Acute beta-adrenergic blockade increases aortic-wave reflection in young women. However, it is not known whether this effect extends to postmenopausal women. We therefore examined the effect of systemic beta-adrenergic blockade on aortic wave reflection in 14 postmenopausal women with a mean age of 58±2 years. Methods Aortic pressure waveforms were synthesized noninvasively from high-fidelity radial pressure waveforms obtained through applanation tonometry before and during systemic beta-blockade with propranolol given in a bolus dose of 0.25mg/kg, followed by a continuous infusion at 0.004mg/kg/min. To further examine the effects of acute beta-blockade on aortic-wave reflection in postmenopausal women, we compared the changes in hemodynamics and indices of aortic-wave reflection with published data from a previous study with a protocol identical to that in the present study but which involved young women. Results Acute beta-blockade increased the aortic augmentation index (AIx) in postmenopausal women (32±2% vs. 35±2%, P < 0.01). However, AIx adjusted for a heart rate of 75 bpm (AIx75) was unchanged (25±2% vs. 24±2%, P > 0.05). The changes in AIx, AIx75, and the amplitude of reflected waves (augmented aortic pressure) during beta-blockade were all substantially smaller in postmenopausal women than in their younger counterparts (P < 0.05).ConclusionsAs compared with those in our previously published study involving young women, indices of aortic-wave reflection were significantly less affected by acute systemic beta-adrenergic blockade in the postmenopausal women in the present study. Taken together, our data suggest that the negative effects (i.e. increased aortic wave reflection) of nonselective beta-adrenergic blockade are less pronounced in postmenopausal than in young women.

AB - Background Acute beta-adrenergic blockade increases aortic-wave reflection in young women. However, it is not known whether this effect extends to postmenopausal women. We therefore examined the effect of systemic beta-adrenergic blockade on aortic wave reflection in 14 postmenopausal women with a mean age of 58±2 years. Methods Aortic pressure waveforms were synthesized noninvasively from high-fidelity radial pressure waveforms obtained through applanation tonometry before and during systemic beta-blockade with propranolol given in a bolus dose of 0.25mg/kg, followed by a continuous infusion at 0.004mg/kg/min. To further examine the effects of acute beta-blockade on aortic-wave reflection in postmenopausal women, we compared the changes in hemodynamics and indices of aortic-wave reflection with published data from a previous study with a protocol identical to that in the present study but which involved young women. Results Acute beta-blockade increased the aortic augmentation index (AIx) in postmenopausal women (32±2% vs. 35±2%, P < 0.01). However, AIx adjusted for a heart rate of 75 bpm (AIx75) was unchanged (25±2% vs. 24±2%, P > 0.05). The changes in AIx, AIx75, and the amplitude of reflected waves (augmented aortic pressure) during beta-blockade were all substantially smaller in postmenopausal women than in their younger counterparts (P < 0.05).ConclusionsAs compared with those in our previously published study involving young women, indices of aortic-wave reflection were significantly less affected by acute systemic beta-adrenergic blockade in the postmenopausal women in the present study. Taken together, our data suggest that the negative effects (i.e. increased aortic wave reflection) of nonselective beta-adrenergic blockade are less pronounced in postmenopausal than in young women.

KW - aortic wave reflection

KW - beta-adrenergic receptors

KW - blood pressure

KW - hypertension

KW - menopause

UR - http://www.scopus.com/inward/record.url?scp=84876558436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876558436&partnerID=8YFLogxK

U2 - 10.1093/ajh/hps074

DO - 10.1093/ajh/hps074

M3 - Article

C2 - 23467206

AN - SCOPUS:84876558436

VL - 26

SP - 503

EP - 510

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 4

ER -